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Molecular phenotyping of small cell lung cancer using targeted cfDNA profiling of transcriptional regulatory regions.
Hiatt JB, Doebley AL, Arnold HU, Adil M, Sandborg H, Persse TW, Ko M, Wu F, Quintanal Villalonga A, Santana-Davila R, Eaton K, Dive C, Rudin CM, Thomas A, Houghton AM, Ha G, MacPherson D. Hiatt JB, et al. Among authors: macpherson d. Sci Adv. 2024 Apr 12;10(15):eadk2082. doi: 10.1126/sciadv.adk2082. Epub 2024 Apr 10. Sci Adv. 2024. PMID: 38598634 Free PMC article.
Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing.
Hiatt JB, Sandborg H, Garrison SM, Arnold HU, Liao SY, Norton JP, Friesen TJ, Wu F, Sutherland KD, Rienhoff HY, Martins R, Houghton AM, Srivastava S, MacPherson D. Hiatt JB, et al. Among authors: macpherson d. Clin Cancer Res. 2022 Oct 14;28(20):4551-4564. doi: 10.1158/1078-0432.CCR-22-1128. Clin Cancer Res. 2022. PMID: 35920742 Free PMC article.
A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA.
Doebley AL, Ko M, Liao H, Cruikshank AE, Santos K, Kikawa C, Hiatt JB, Patton RD, De Sarkar N, Collier KA, Hoge ACH, Chen K, Zimmer A, Weber ZT, Adil M, Reichel JB, Polak P, Adalsteinsson VA, Nelson PS, MacPherson D, Parsons HA, Stover DG, Ha G. Doebley AL, et al. Among authors: macpherson d. Nat Commun. 2022 Dec 3;13(1):7475. doi: 10.1038/s41467-022-35076-w. Nat Commun. 2022. PMID: 36463275 Free PMC article.
Lung Cancer Subtypes Generate Unique Immune Responses.
Busch SE, Hanke ML, Kargl J, Metz HE, MacPherson D, Houghton AM. Busch SE, et al. Among authors: macpherson d. J Immunol. 2016 Dec 1;197(11):4493-4503. doi: 10.4049/jimmunol.1600576. Epub 2016 Oct 31. J Immunol. 2016. PMID: 27799309 Free PMC article.
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition.
Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton KD, Martins R, Poirier JT, Rudin CM, Milletti F, Cheng WY, Mack F, MacPherson D. Augert A, et al. Among authors: macpherson d. Sci Signal. 2019 Feb 5;12(567):eaau2922. doi: 10.1126/scisignal.aau2922. Sci Signal. 2019. PMID: 30723171 Free PMC article.
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.
Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF. Rudin CM, et al. Among authors: macpherson d. Nat Rev Cancer. 2019 May;19(5):289-297. doi: 10.1038/s41568-019-0133-9. Nat Rev Cancer. 2019. PMID: 30926931 Free PMC article. Review.
MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity.
Grunblatt E, Wu N, Zhang H, Liu X, Norton JP, Ohol Y, Leger P, Hiatt JB, Eastwood EC, Thomas R, Ibrahim AH, Jia D, Basom R, Eaton KD, Martins R, Houghton AM, MacPherson D. Grunblatt E, et al. Among authors: macpherson d. Genes Dev. 2020 Sep 1;34(17-18):1210-1226. doi: 10.1101/gad.340133.120. Epub 2020 Aug 20. Genes Dev. 2020. PMID: 32820040 Free PMC article.
Posttranslational modifications induce autoantibodies with risk prediction capability in patients with small cell lung cancer.
Lastwika KJ, Kunihiro A, Solan JL, Zhang Y, Taverne LR, Shelley D, Rho JH, Randolph TW, Li CI, Grogan EL, Massion PP, Fitzpatrick AL, MacPherson D, Houghton AM, Lampe PD. Lastwika KJ, et al. Among authors: macpherson d. Sci Transl Med. 2023 Jan 11;15(678):eadd8469. doi: 10.1126/scitranslmed.add8469. Epub 2023 Jan 11. Sci Transl Med. 2023. PMID: 36630482 Free PMC article.
263 results