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Persistent TFIIH binding to non-excised DNA damage causes cell and developmental failure.
Muniesa-Vargas A, Davó-Martínez C, Ribeiro-Silva C, van der Woude M, Thijssen KL, Haspels B, Häckes D, Kaynak ÜU, Kanaar R, Marteijn JA, Theil AF, Kuijten MMP, Vermeulen W, Lans H. Muniesa-Vargas A, et al. Among authors: hackes d. Nat Commun. 2024 Apr 25;15(1):3490. doi: 10.1038/s41467-024-47935-9. Nat Commun. 2024. PMID: 38664429 Free PMC article.
Transcription-coupled DNA-protein crosslink repair by CSB and CRL4CSA-mediated degradation.
van Sluis M, Yu Q, van der Woude M, Gonzalo-Hansen C, Dealy SC, Janssens RC, Somsen HB, Ramadhin AR, Dekkers DHW, Wienecke HL, Demmers JJPG, Raams A, Davó-Martínez C, Llerena Schiffmacher DA, van Toorn M, Häckes D, Thijssen KL, Zhou D, Lammers JG, Pines A, Vermeulen W, Pothof J, Demmers JAA, van den Berg DLC, Lans H, Marteijn JA. van Sluis M, et al. Among authors: hackes d. Nat Cell Biol. 2024 May;26(5):770-783. doi: 10.1038/s41556-024-01394-y. Epub 2024 Apr 10. Nat Cell Biol. 2024. PMID: 38600236 Free PMC article.
Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy.
Slyskova J, Muniesa-Vargas A, da Silva IT, Drummond R, Park J, Häckes D, Poetsch I, Ribeiro-Silva C, Moretton A, Heffeter P, Schärer OD, Vermeulen W, Lans H, Loizou JI. Slyskova J, et al. Among authors: hackes d. NAR Cancer. 2023 Dec 5;5(4):zcad057. doi: 10.1093/narcan/zcad057. eCollection 2023 Dec. NAR Cancer. 2023. PMID: 38058548 Free PMC article.