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IMPROVE: a feature model to predict neoepitope immunogenicity through broad-scale validation of T-cell recognition.
Borch A, Carri I, Reynisson B, Alvarez HMG, Munk KK, Montemurro A, Kristensen NP, Tvingsholm SA, Holm JS, Heeke C, Moss KH, Hansen UK, Schaap-Johansen AL, Bagger FO, de Lima VAB, Rohrberg KS, Funt SA, Donia M, Svane IM, Lassen U, Barra C, Nielsen M, Hadrup SR. Borch A, et al. Among authors: tvingsholm sa. Front Immunol. 2024 Apr 3;15:1360281. doi: 10.3389/fimmu.2024.1360281. eCollection 2024. Front Immunol. 2024. PMID: 38633261 Free PMC article.
Cross-reactive CD8+ T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs).
Cavalluzzo B, Viuff MC, Tvingsholm SA, Ragone C, Manolio C, Mauriello A, Buonaguro FM, Tornesello ML, Izzo F, Morabito A, Hadrup SR, Tagliamonte M, Buonaguro L. Cavalluzzo B, et al. Among authors: tvingsholm sa. J Exp Clin Cancer Res. 2024 Mar 20;43(1):87. doi: 10.1186/s13046-024-03004-z. J Exp Clin Cancer Res. 2024. PMID: 38509571 Free PMC article.
TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy.
Tvingsholm SA, Frej MS, Rafa VM, Hansen UK, Ormhøj M, Tyron A, Jensen AWP, Kadivar M, Bentzen AK, Munk KK, Aasbjerg GN, Ternander JSH, Heeke C, Tamhane T, Schmess C, Funt SA, Kjeldsen JW, Kverneland AH, Met Ö, Draghi A, Jakobsen SN, Donia M, Marie Svane I, Hadrup SR. Tvingsholm SA, et al. J Immunother Cancer. 2023 Aug;11(8):e006847. doi: 10.1136/jitc-2023-006847. J Immunother Cancer. 2023. PMID: 37586765 Free PMC article.
Dynamics of Melanoma-Associated Epitope-Specific CD8+ T Cells in the Blood Correlate With Clinical Outcome Under PD-1 Blockade.
Gaißler A, Meldgaard TS, Heeke C, Babaei S, Tvingsholm SA, Bochem J, Spreuer J, Amaral T, Wagner NB, Klein R, Meier F, Garbe C, Eigentler TK, Pawelec G, Claassen M, Weide B, Hadrup SR, Wistuba-Hamprecht K. Gaißler A, et al. Among authors: tvingsholm sa. Front Immunol. 2022 Jul 7;13:906352. doi: 10.3389/fimmu.2022.906352. eCollection 2022. Front Immunol. 2022. PMID: 35874702 Free PMC article.
Novel Molecular Targets for Hepatocellular Carcinoma.
Cavalluzzo B, Mauriello A, Ragone C, Manolio C, Tornesello ML, Buonaguro FM, Tvingsholm SA, Hadrup SR, Tagliamonte M, Buonaguro L. Cavalluzzo B, et al. Among authors: tvingsholm sa. Cancers (Basel). 2021 Dec 28;14(1):140. doi: 10.3390/cancers14010140. Cancers (Basel). 2021. PMID: 35008303 Free PMC article.
Neoantigen-reactive CD8+ T cells affect clinical outcome of adoptive cell therapy with tumor-infiltrating lymphocytes in melanoma.
Kristensen NP, Heeke C, Tvingsholm SA, Borch A, Draghi A, Crowther MD, Carri I, Munk KK, Holm JS, Bjerregaard AM, Bentzen AK, Marquard AM, Szallasi Z, McGranahan N, Andersen R, Nielsen M, Jönsson GB, Donia M, Svane IM, Hadrup SR. Kristensen NP, et al. Among authors: tvingsholm sa. J Clin Invest. 2022 Jan 18;132(2):e150535. doi: 10.1172/JCI150535. J Clin Invest. 2022. PMID: 34813506 Free PMC article. Clinical Trial.
Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion.
Brix DM, Tvingsholm SA, Hansen MB, Clemmensen KB, Ohman T, Siino V, Lambrughi M, Hansen K, Puustinen P, Gromova I, James P, Papaleo E, Varjosalo M, Moreira J, Jäättelä M, Kallunki T. Brix DM, et al. Among authors: tvingsholm sa. Oncogene. 2019 Apr;38(17):3170-3184. doi: 10.1038/s41388-018-0653-x. Epub 2019 Jan 8. Oncogene. 2019. PMID: 30622337 Free PMC article.
Proton pump inhibitor use and cancer mortality.
Tvingsholm SA, Dehlendorff C, Østerlind K, Friis S, Jäättelä M. Tvingsholm SA, et al. Int J Cancer. 2018 Sep 15;143(6):1315-1326. doi: 10.1002/ijc.31529. Epub 2018 May 2. Int J Cancer. 2018. PMID: 29658114 Free PMC article.