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Page 1
Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions.
McCarver S, Hanna L, Samant A, Thompson AA, Seierstad M, Saha A, Wu D, Lord B, Sutton SW, Shah V, Milligan CM, Wennerholm M, Shelton J, Lebold TP, Shireman BT. McCarver S, et al. Among authors: shelton j. ACS Med Chem Lett. 2024 Mar 7;15(4):486-492. doi: 10.1021/acsmedchemlett.3c00523. eCollection 2024 Apr 11. ACS Med Chem Lett. 2024. PMID: 38628796
A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects.
Bonaventure P, Yun S, Johnson PL, Shekhar A, Fitz SD, Shireman BT, Lebold TP, Nepomuceno D, Lord B, Wennerholm M, Shelton J, Carruthers N, Lovenberg T, Dugovic C. Bonaventure P, et al. Among authors: shelton j. J Pharmacol Exp Ther. 2015 Mar;352(3):590-601. doi: 10.1124/jpet.114.220392. Epub 2015 Jan 12. J Pharmacol Exp Ther. 2015. PMID: 25583879 Free PMC article.
Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.
Letavic MA, Aluisio L, Apodaca R, Bajpai M, Barbier AJ, Bonneville A, Bonaventure P, Carruthers NI, Dugovic C, Fraser IC, Kramer ML, Lord B, Lovenberg TW, Li LY, Ly KS, Mcallister H, Mani NS, Morton KL, Ndifor A, Nepomuceno SD, Pandit CR, Sands SB, Shah CR, Shelton JE, Snook SS, Swanson DM, Xiao W. Letavic MA, et al. Among authors: shelton je. ACS Med Chem Lett. 2015 Mar 13;6(4):450-4. doi: 10.1021/ml5005156. eCollection 2015 Apr 9. ACS Med Chem Lett. 2015. PMID: 25893048 Free PMC article.
R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.
Kuei C, Sutton S, Bonaventure P, Pudiak C, Shelton J, Zhu J, Nepomuceno D, Wu J, Chen J, Kamme F, Seierstad M, Hack MD, Bathgate RA, Hossain MA, Wade JD, Atack J, Lovenberg TW, Liu C. Kuei C, et al. Among authors: shelton j. J Biol Chem. 2007 Aug 31;282(35):25425-35. doi: 10.1074/jbc.M701416200. Epub 2007 Jul 2. J Biol Chem. 2007. PMID: 17606621 Free article.
Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines.
Dvorak CA, Apodaca R, Xiao W, Jablonowski JA, Bonaventure P, Dugovic C, Shelton J, Lord B, Miller K, Dvorak LK, Lovenberg TW, Carruthers NI. Dvorak CA, et al. Among authors: shelton j. Eur J Med Chem. 2009 Oct;44(10):4098-106. doi: 10.1016/j.ejmech.2009.04.049. Epub 2009 May 13. Eur J Med Chem. 2009. PMID: 19524331
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.
Stocking EM, Aluisio L, Atack JR, Bonaventure P, Carruthers NI, Dugovic C, Everson A, Fraser I, Jiang X, Leung P, Lord B, Ly KS, Morton KL, Nepomuceno D, Shah CR, Shelton J, Soyode-Johnson A, Letavic MA. Stocking EM, et al. Among authors: shelton j. Bioorg Med Chem Lett. 2010 May 1;20(9):2755-60. doi: 10.1016/j.bmcl.2010.03.071. Epub 2010 Mar 20. Bioorg Med Chem Lett. 2010. PMID: 20382018
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.
Bonaventure P, Shelton J, Yun S, Nepomuceno D, Sutton S, Aluisio L, Fraser I, Lord B, Shoblock J, Welty N, Chaplan SR, Aguilar Z, Halter R, Ndifor A, Koudriakova T, Rizzolio M, Letavic M, Carruthers NI, Lovenberg T, Dugovic C. Bonaventure P, et al. Among authors: shelton j. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82. doi: 10.1124/jpet.115.225466. Epub 2015 Jul 15. J Pharmacol Exp Ther. 2015. PMID: 26177655
1,252 results