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Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions.
McCarver S, Hanna L, Samant A, Thompson AA, Seierstad M, Saha A, Wu D, Lord B, Sutton SW, Shah V, Milligan CM, Wennerholm M, Shelton J, Lebold TP, Shireman BT. McCarver S, et al. Among authors: shireman bt. ACS Med Chem Lett. 2024 Mar 7;15(4):486-492. doi: 10.1021/acsmedchemlett.3c00523. eCollection 2024 Apr 11. ACS Med Chem Lett. 2024. PMID: 38628796
Selective orexin receptor antagonists.
Lebold TP, Bonaventure P, Shireman BT. Lebold TP, et al. Among authors: shireman bt. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4761-9. doi: 10.1016/j.bmcl.2013.06.057. Epub 2013 Jul 4. Bioorg Med Chem Lett. 2013. PMID: 23891187 Review.
A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects.
Bonaventure P, Yun S, Johnson PL, Shekhar A, Fitz SD, Shireman BT, Lebold TP, Nepomuceno D, Lord B, Wennerholm M, Shelton J, Carruthers N, Lovenberg T, Dugovic C. Bonaventure P, et al. Among authors: shireman bt. J Pharmacol Exp Ther. 2015 Mar;352(3):590-601. doi: 10.1124/jpet.114.220392. Epub 2015 Jan 12. J Pharmacol Exp Ther. 2015. PMID: 25583879 Free PMC article.
Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.
Préville C, Bonaventure P, Koudriakova T, Lord B, Nepomuceno D, Rizzolio M, Mani N, Coe KJ, Ndifor A, Dugovic C, Dvorak CA, Coate H, Pippel DJ, Fitzgerald A, Allison B, Lovenberg TW, Carruthers NI, Shireman BT. Préville C, et al. Among authors: shireman bt. ACS Med Chem Lett. 2020 Apr 27;11(10):2002-2009. doi: 10.1021/acsmedchemlett.0c00085. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062185 Free PMC article.
Substituted 5,6-(Dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-methanones as P2X7 Antagonists.
Ziff J, Rudolph DA, Stenne B, Koudriakova T, Lord B, Bonaventure P, Lovenberg TW, Carruthers NI, Bhattacharya A, Letavic MA, Shireman BT. Ziff J, et al. Among authors: shireman bt. ACS Chem Neurosci. 2016 Apr 20;7(4):498-504. doi: 10.1021/acschemneuro.5b00304. Epub 2016 Jan 19. ACS Chem Neurosci. 2016. PMID: 26754558
Copper-mediated synthesis of drug-like bicyclopentanes.
Zhang X, Smith RT, Le C, McCarver SJ, Shireman BT, Carruthers NI, MacMillan DWC. Zhang X, et al. Among authors: shireman bt. Nature. 2020 Apr;580(7802):220-226. doi: 10.1038/s41586-020-2060-z. Epub 2020 Feb 17. Nature. 2020. PMID: 32066140 Free PMC article.
Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans.
Salvadore G, Bonaventure P, Shekhar A, Johnson PL, Lord B, Shireman BT, Lebold TP, Nepomuceno D, Dugovic C, Brooks S, Zuiker R, Bleys C, Tatikola K, Remmerie B, Jacobs GE, Schruers K, Moyer J, Nash A, Van Nueten LGM, Drevets WC. Salvadore G, et al. Among authors: shireman bt. Transl Psychiatry. 2020 Sep 7;10(1):308. doi: 10.1038/s41398-020-00937-9. Transl Psychiatry. 2020. PMID: 32895369 Free PMC article.
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