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The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1.
Romero R, Chu T, González-Robles TJ, Smith P, Xie Y, Kaur H, Yoder S, Zhao H, Mao C, Kang W, Pulina MV, Lawrence KE, Gopalan A, Zaidi S, Yoo K, Choi J, Fan N, Gerstner O, Karthaus WR, DeStanchina E, Ruggles KV, Westcott PMK, Chaligné R, Pe'er D, Sawyers CL. Romero R, et al. Among authors: karthaus wr. bioRxiv [Preprint]. 2024 Apr 11:2024.04.09.588557. doi: 10.1101/2024.04.09.588557. bioRxiv. 2024. PMID: 38645223 Free PMC article. Preprint.
Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies.
Zaidi S, Park J, Chan JM, Roudier MP, Zhao JL, Gopalan A, Wadosky KM, Patel RA, Sayar E, Karthaus WR, Henry Kates D, Chaudhary O, Xu T, Masilionis I, Mazutis L, Chaligné R, Obradovic A, Linkov I, Barlas A, Jungbluth A, Rekhtman N, Silber J, Manova-Todorova K, Watson PA, True LD, Morrissey CM, Scher HI, Rathkopf D, Morris MJ, Goodrich DW, Choi J, Nelson PS, Haffner MC, Sawyers CL. Zaidi S, et al. Among authors: karthaus wr. bioRxiv [Preprint]. 2024 Apr 12:2024.04.09.588340. doi: 10.1101/2024.04.09.588340. bioRxiv. 2024. PMID: 38645034 Free PMC article. Preprint.
Next-Generation Modeling of Cancer Using Organoids.
Love JR, Karthaus WR. Love JR, et al. Among authors: karthaus wr. Cold Spring Harb Perspect Med. 2023 Sep 21:a041380. doi: 10.1101/cshperspect.a041380. Online ahead of print. Cold Spring Harb Perspect Med. 2023. PMID: 37734867
Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers.
Quintanal-Villalonga A, Durani V, Sabet A, Redin E, Kawasaki K, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Shah NS, Chow A, Bhanot UK, Linkov I, Asher M, Yu HA, Qiu J, de Stanchina E, Patel RA, Morrissey C, Haffner MC, Koche RP, Sawyers CL, Rudin CM. Quintanal-Villalonga A, et al. Among authors: karthaus wr. Sci Transl Med. 2023 Aug 2;15(707):eadf7006. doi: 10.1126/scitranslmed.adf7006. Epub 2023 Aug 2. Sci Transl Med. 2023. PMID: 37531417 Free PMC article.
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling.
Chan JM, Zaidi S, Love JR, Zhao JL, Setty M, Wadosky KM, Gopalan A, Choo ZN, Persad S, Choi J, LaClair J, Lawrence KE, Chaudhary O, Xu T, Masilionis I, Linkov I, Wang S, Lee C, Barlas A, Morris MJ, Mazutis L, Chaligne R, Chen Y, Goodrich DW, Karthaus WR, Pe'er D, Sawyers CL. Chan JM, et al. Among authors: karthaus wr. Science. 2022 Sep 9;377(6611):1180-1191. doi: 10.1126/science.abn0478. Epub 2022 Aug 18. Science. 2022. PMID: 35981096 Free PMC article.
Allosteric interactions prime androgen receptor dimerization and activation.
Wasmuth EV, Broeck AV, LaClair JR, Hoover EA, Lawrence KE, Paknejad N, Pappas K, Matthies D, Wang B, Feng W, Watson PA, Zinder JC, Karthaus WR, de la Cruz MJ, Hite RK, Manova-Todorova K, Yu Z, Weintraub ST, Klinge S, Sawyers CL. Wasmuth EV, et al. Among authors: karthaus wr. Mol Cell. 2022 Jun 2;82(11):2021-2031.e5. doi: 10.1016/j.molcel.2022.03.035. Epub 2022 Apr 20. Mol Cell. 2022. PMID: 35447082 Free PMC article.
Reovirus mutant jin-3 exhibits lytic and immune-stimulatory effects in preclinical human prostate cancer models.
van de Merbel AF, van der Horst G, van der Mark MH, Bots STF, van den Wollenberg DJM, de Ridder CMA, Stuurman D, Aalders T, Erkens-Schulz S, van Montfoort N, Karthaus WR, Mehra N, Smits M, Schalken JA, van Weerden WM, Hoeben RC, van der Pluijm G. van de Merbel AF, et al. Among authors: karthaus wr. Cancer Gene Ther. 2022 Jun;29(6):793-802. doi: 10.1038/s41417-021-00360-2. Epub 2021 Jun 16. Cancer Gene Ther. 2022. PMID: 34135475 Free PMC article.
FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer.
Arruabarrena-Aristorena A, Maag JLV, Kittane S, Cai Y, Karthaus WR, Ladewig E, Park J, Kannan S, Ferrando L, Cocco E, Ho SY, Tan DS, Sallaku M, Wu F, Acevedo B, Selenica P, Ross DS, Witkin M, Sawyers CL, Reis-Filho JS, Verma CS, Jauch R, Koche R, Baselga J, Razavi P, Toska E, Scaltriti M. Arruabarrena-Aristorena A, et al. Among authors: karthaus wr. Cancer Cell. 2020 Oct 12;38(4):534-550.e9. doi: 10.1016/j.ccell.2020.08.003. Epub 2020 Sep 3. Cancer Cell. 2020. PMID: 32888433 Free PMC article.
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer.
Zhang Z, Karthaus WR, Lee YS, Gao VR, Wu C, Russo JW, Liu M, Mota JM, Abida W, Linton E, Lee E, Barnes SD, Chen HA, Mao N, Wongvipat J, Choi D, Chen X, Zhao H, Manova-Todorova K, de Stanchina E, Taplin ME, Balk SP, Rathkopf DE, Gopalan A, Carver BS, Mu P, Jiang X, Watson PA, Sawyers CL. Zhang Z, et al. Among authors: karthaus wr. Cancer Cell. 2020 Aug 10;38(2):279-296.e9. doi: 10.1016/j.ccell.2020.06.005. Epub 2020 Jul 16. Cancer Cell. 2020. PMID: 32679108 Free PMC article.
27 results