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Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.
Oorloff M, Hruby A, Averbukh M, Alcala A, Dutta N, Torres TC, Moaddeli D, Vega M, Kim J, Bong A, Coakley AJ, Hicks D, Wang J, Wang T, Hoang S, Tharp KM, Garcia G, Higuchi-Sanabria R. Oorloff M, et al. Among authors: garcia g. bioRxiv [Preprint]. 2024 Apr 12:2024.04.11.589121. doi: 10.1101/2024.04.11.589121. bioRxiv. 2024. PMID: 38645203 Free PMC article. Preprint.
Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization.
Moehle EA, Higuchi-Sanabria R, Tsui CK, Homentcovschi S, Tharp KM, Zhang H, Chi H, Joe L, de Los Rios Rogers M, Sahay A, Kelet N, Benitez C, Bar-Ziv R, Garcia G, Shen K, Frankino PA, Schinzel RT, Shalem O, Dillin A. Moehle EA, et al. Among authors: garcia g. Sci Adv. 2021 Oct 29;7(44):eabj6818. doi: 10.1126/sciadv.abj6818. Epub 2021 Oct 29. Sci Adv. 2021. PMID: 34714674 Free PMC article.
Hijacking Cellular Stress Responses to Promote Lifespan.
Dutta N, Garcia G, Higuchi-Sanabria R. Dutta N, et al. Among authors: garcia g. Front Aging. 2022 Mar 24;3:860404. doi: 10.3389/fragi.2022.860404. eCollection 2022. Front Aging. 2022. PMID: 35821861 Free PMC article. Review.
More than a loading control: actin regulation in aging.
Averbukh M, Garcia G, Higuchi-Sanabria R. Averbukh M, et al. Among authors: garcia g. Aging (Albany NY). 2023 May 18;15(10):3896-3898. doi: 10.18632/aging.204746. Epub 2023 May 18. Aging (Albany NY). 2023. PMID: 37204421 Free PMC article. No abstract available.
Glial-derived mitochondrial signals impact neuronal proteostasis and aging.
Bar-Ziv R, Dutta N, Hruby A, Sukarto E, Averbukh M, Alcala A, Henderson HR, Durieux J, Tronnes SU, Ahmad Q, Bolas T, Perez J, Dishart JG, Vega M, Garcia G, Higuchi-Sanabria R, Dillin A. Bar-Ziv R, et al. Among authors: garcia g. bioRxiv [Preprint]. 2023 Aug 8:2023.07.20.549924. doi: 10.1101/2023.07.20.549924. bioRxiv. 2023. PMID: 37609253 Free PMC article. Updated. Preprint.
Glial-derived mitochondrial signals affect neuronal proteostasis and aging.
Bar-Ziv R, Dutta N, Hruby A, Sukarto E, Averbukh M, Alcala A, Henderson HR, Durieux J, Tronnes SU, Ahmad Q, Bolas T, Perez J, Dishart JG, Vega M, Garcia G, Higuchi-Sanabria R, Dillin A. Bar-Ziv R, et al. Among authors: garcia g. Sci Adv. 2023 Oct 13;9(41):eadi1411. doi: 10.1126/sciadv.adi1411. Epub 2023 Oct 13. Sci Adv. 2023. PMID: 37831769 Free PMC article.
2,794 results