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Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator.
Nat Commun. 2024 Apr 25;15(1):3523. doi: 10.1038/s41467-024-47761-z.
Nat Commun. 2024.
PMID: 38664421
Free PMC article.
Characterizing Time-of-Day Conformational Changes in the Intrinsically Disordered Proteins of the Circadian Clock.
Pelham JF, Mosier AE, Hurley JM.
Pelham JF, et al.
Methods Enzymol. 2018;611:503-529. doi: 10.1016/bs.mie.2018.08.024. Epub 2018 Sep 25.
Methods Enzymol. 2018.
PMID: 30471697
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Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit.
Pelham JF, Dunlap JC, Hurley JM.
Pelham JF, et al.
Cell Commun Signal. 2020 Nov 11;18(1):181. doi: 10.1186/s12964-020-00658-y.
Cell Commun Signal. 2020.
PMID: 33176800
Free PMC article.
Review.
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Conformational changes in the negative arm of the circadian clock correlate with dynamic interactomes involved in post-transcriptional regulation.
Pelham JF, Mosier AE, Altshuler SC, Rhodes ML, Kirchhoff CL, Fall WB, Mann C, Baik LS, Chiu JC, Hurley JM.
Pelham JF, et al.
Cell Rep. 2023 Apr 25;42(4):112376. doi: 10.1016/j.celrep.2023.112376. Epub 2023 Apr 10.
Cell Rep. 2023.
PMID: 37043358
Free PMC article.
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