Elledge SJ - Search Results

1

Mechanism of Ψ-Pro/C-degron recognition by the CRL2^FEM1B ubiquitin ligase.

Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C. Chen X, et al. Among authors: elledge sj. Nat Commun. 2024 Apr 26;15(1):3558. doi: 10.1038/s41467-024-47890-5. Nat Commun. 2024. PMID: 38670995 Free PMC article.

2

A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.

Timms RT, Zhang Z, Rhee DY, Harper JW, Koren I, Elledge SJ. Timms RT, et al. Among authors: elledge sj. Science. 2019 Jul 5;365(6448):eaaw4912. doi: 10.1126/science.aaw4912. Science. 2019. PMID: 31273098 Free PMC article.

3

Defining E3 ligase-substrate relationships through multiplex CRISPR screening.

Timms RT, Mena EL, Leng Y, Li MZ, Tchasovnikarova IA, Koren I, Elledge SJ. Timms RT, et al. Among authors: elledge sj. Nat Cell Biol. 2023 Oct;25(10):1535-1545. doi: 10.1038/s41556-023-01229-2. Epub 2023 Sep 21. Nat Cell Biol. 2023. PMID: 37735597 Free PMC article.

4

The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.

Koren I, Timms RT, Kula T, Xu Q, Li MZ, Elledge SJ. Koren I, et al. Among authors: elledge sj. Cell. 2018 Jun 14;173(7):1622-1635.e14. doi: 10.1016/j.cell.2018.04.028. Epub 2018 May 17. Cell. 2018. PMID: 29779948 Free PMC article.

5

Author Correction: Defining E3 ligase-substrate relationships through multiplex CRISPR screening.

Timms RT, Mena EL, Leng Y, Li MZ, Tchasovnikarova IA, Koren I, Elledge SJ. Timms RT, et al. Among authors: elledge sj. Nat Cell Biol. 2024 Feb;26(2):305. doi: 10.1038/s41556-023-01336-0. Nat Cell Biol. 2024. PMID: 38114738 Free PMC article. No abstract available.

6

High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform.

Bruno PM, Timms RT, Abdelfattah NS, Leng Y, Lelis FJN, Wesemann DR, Yu XG, Elledge SJ. Bruno PM, et al. Among authors: elledge sj. Nat Biotechnol. 2023 Jul;41(7):980-992. doi: 10.1038/s41587-022-01566-x. Epub 2023 Jan 2. Nat Biotechnol. 2023. PMID: 36593401 Free PMC article.

7

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.

Elia AE, Boardman AP, Wang DC, Huttlin EL, Everley RA, Dephoure N, Zhou C, Koren I, Gygi SP, Elledge SJ. Elia AE, et al. Among authors: elledge sj. Mol Cell. 2015 Sep 3;59(5):867-81. doi: 10.1016/j.molcel.2015.05.006. Epub 2015 Jun 4. Mol Cell. 2015. PMID: 26051181 Free PMC article.

8

Systematic characterization of mutations altering protein degradation in human cancers.

Tokheim C, Wang X, Timms RT, Zhang B, Mena EL, Wang B, Chen C, Ge J, Chu J, Zhang W, Elledge SJ, Brown M, Liu XS. Tokheim C, et al. Among authors: elledge sj. Mol Cell. 2021 Mar 18;81(6):1292-1308.e11. doi: 10.1016/j.molcel.2021.01.020. Epub 2021 Feb 9. Mol Cell. 2021. PMID: 33567269 Free PMC article.

9

Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses.

Shrock EL, Timms RT, Kula T, Mena EL, West AP Jr, Guo R, Lee IH, Cohen AA, McKay LGA, Bi C, Leng Y, Fujimura E, Horns F, Li M, Wesemann DR, Griffiths A, Gewurz BE, Bjorkman PJ, Elledge SJ. Shrock EL, et al. Among authors: elledge sj. Science. 2023 Apr 7;380(6640):eadc9498. doi: 10.1126/science.adc9498. Epub 2023 Apr 7. Science. 2023. PMID: 37023193 Free PMC article.

10

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.

Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP. Zheng N, et al. Among authors: elledge sj. Nature. 2002 Apr 18;416(6882):703-9. doi: 10.1038/416703a. Nature. 2002. PMID: 11961546

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