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The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex.
Papadopoulos D, Ha SA, Fleischhauer D, Uhl L, Russell TJ, Mikicic I, Schneider K, Brem A, Valanju OR, Cossa G, Gallant P, Schuelein-Voelk C, Maric HM, Beli P, Büchel G, Vos SM, Eilers M. Papadopoulos D, et al. Among authors: ha sa. Mol Cell. 2024 Jun 6;84(11):2070-2086.e20. doi: 10.1016/j.molcel.2024.04.007. Epub 2024 May 3. Mol Cell. 2024. PMID: 38703770 Free article.
MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts.
Papadopoulos D, Solvie D, Baluapuri A, Endres T, Ha SA, Herold S, Kalb J, Giansanti C, Schülein-Völk C, Ade CP, Schneider C, Gaballa A, Vos S, Fischer U, Dobbelstein M, Wolf E, Eilers M. Papadopoulos D, et al. Among authors: ha sa. Mol Cell. 2022 Jan 6;82(1):159-176.e12. doi: 10.1016/j.molcel.2021.11.002. Epub 2021 Nov 29. Mol Cell. 2022. PMID: 34847357 Free article.
Beyond gene expression: how MYC relieves transcription stress.
Papadopoulos D, Uhl L, Ha SA, Eilers M. Papadopoulos D, et al. Among authors: ha sa. Trends Cancer. 2023 Oct;9(10):805-816. doi: 10.1016/j.trecan.2023.06.008. Epub 2023 Jul 7. Trends Cancer. 2023. PMID: 37422352 Review.
ITIH5 as a multifaceted player in pancreatic cancer suppression, impairing tyrosine kinase signaling, cell adhesion and migration.
Kosinski J, Sechi A, Hain J, Villwock S, Ha SA, Hauschulz M, Rose M, Steib F, Ortiz-Brüchle N, Heij L, Maas SL, van der Vorst EPC, Knoesel T, Altendorf-Hofmann A, Simon R, Sauter G, Bednarsch J, Jonigk D, Dahl E. Kosinski J, et al. Among authors: ha sa. Mol Oncol. 2024 Jun;18(6):1486-1509. doi: 10.1002/1878-0261.13609. Epub 2024 Feb 20. Mol Oncol. 2024. PMID: 38375974 Free PMC article.
40 results