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Itaconate controls the severity of pulmonary fibrosis.
Ogger PP, Albers GJ, Hewitt RJ, O'Sullivan BJ, Powell JE, Calamita E, Ghai P, Walker SA, McErlean P, Saunders P, Kingston S, Molyneaux PL, Halket JM, Gray R, Chambers DC, Maher TM, Lloyd CM, Byrne AJ. Ogger PP, et al. Sci Immunol. 2020 Oct 23;5(52):eabc1884. doi: 10.1126/sciimmunol.abc1884. Sci Immunol. 2020. PMID: 33097591 Free PMC article.
Bacterial burden in the lower airways predicts disease progression in idiopathic pulmonary fibrosis and is independent of radiological disease extent.
Invernizzi R, Barnett J, Rawal B, Nair A, Ghai P, Kingston S, Chua F, Wu Z, Wells AU, Renzoni ER, Nicholson AG, Rice A, Lloyd CM, Byrne AJ, Maher TM, Devaraj A, Molyneaux PL. Invernizzi R, et al. Eur Respir J. 2020 Apr 3;55(4):1901519. doi: 10.1183/13993003.01519-2019. Print 2020 Apr. Eur Respir J. 2020. PMID: 31980496 Free PMC article.