FDN143312/CIHR/Canada[Grants and Funding] - Search Results

Year	Number of Results
2017	1
2018	2
2019	2
2020	5
2021	3
2022	2
2023	2
2024	0

1

Bcl-xL acts as an inhibitor of IP₃R channels, thereby antagonizing Ca²⁺-driven apoptosis.

Rosa N, Ivanova H, Wagner LE 2nd, Kale J, La Rovere R, Welkenhuyzen K, Louros N, Karamanou S, Shabardina V, Lemmens I, Vandermarliere E, Hamada K, Ando H, Rousseau F, Schymkowitz J, Tavernier J, Mikoshiba K, Economou A, Andrews DW, Parys JB, Yule DI, Bultynck G. Rosa N, et al. Cell Death Differ. 2022 Apr;29(4):788-805. doi: 10.1038/s41418-021-00894-w. Epub 2021 Nov 8. Cell Death Differ. 2022. PMID: 34750538 Free PMC article.

2

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.

Wei Y, Redel C, Ahlner A, Lemak A, Johansson-Åkhe I, Houliston S, Kenney TMG, Tamachi A, Morad V, Duan S, Andrews DW, Wallner B, Sunnerhagen M, Arrowsmith CH, Penn LZ. Wei Y, et al. Nucleic Acids Res. 2022 Apr 8;50(6):3505-3522. doi: 10.1093/nar/gkac138. Nucleic Acids Res. 2022. PMID: 35244724 Free PMC article.

3

Image-Based Analysis of Protein Stability.

Hickman KA, Hariharan S, De Melo J, Ylanko J, Lustig LC, Penn LZ, Andrews DW. Hickman KA, et al. Cytometry A. 2020 Apr;97(4):363-377. doi: 10.1002/cyto.a.23928. Epub 2019 Nov 27. Cytometry A. 2020. PMID: 31774248 Free PMC article.

4

Pharmacological Targeting of Executioner Proteins: Controlling Life and Death.

Pogmore JP, Uehling D, Andrews DW. Pogmore JP, et al. J Med Chem. 2021 May 13;64(9):5276-5290. doi: 10.1021/acs.jmedchem.0c02200. Epub 2021 May 3. J Med Chem. 2021. PMID: 33939407 Free article. Review.

5

BCL-2 family proteins: changing partners in the dance towards death.

Kale J, Osterlund EJ, Andrews DW. Kale J, et al. Cell Death Differ. 2018 Jan;25(1):65-80. doi: 10.1038/cdd.2017.186. Epub 2017 Nov 17. Cell Death Differ. 2018. PMID: 29149100 Free PMC article. Review.

6

The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes.

Pemberton JM, Nguyen D, Osterlund EJ, Schormann W, Pogmore JP, Hirmiz N, Leber B, Andrews DW. Pemberton JM, et al. Elife. 2023 Apr 20;12:e88329. doi: 10.7554/eLife.88329. Elife. 2023. PMID: 37078707 Free PMC article.

7

Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins.

Pemberton JM, Pogmore JP, Andrews DW. Pemberton JM, et al. Cell Death Differ. 2021 Jan;28(1):108-122. doi: 10.1038/s41418-020-00654-2. Epub 2020 Nov 8. Cell Death Differ. 2021. PMID: 33162554 Free PMC article. Review.

8

Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins.

Osterlund EJ, Hirmiz N, Nguyen D, Pemberton JM, Fang Q, Andrews DW. Osterlund EJ, et al. J Biol Chem. 2023 Feb;299(2):102863. doi: 10.1016/j.jbc.2022.102863. Epub 2023 Jan 2. J Biol Chem. 2023. PMID: 36603764 Free PMC article.

9

Allosteric Regulation of BH3 Proteins in Bcl-x_L Complexes Enables Switch-like Activation of Bax.

Bogner C, Kale J, Pogmore J, Chi X, Shamas-Din A, Fradin C, Leber B, Andrews DW. Bogner C, et al. Mol Cell. 2020 Feb 20;77(4):901-912.e9. doi: 10.1016/j.molcel.2019.12.025. Epub 2020 Jan 27. Mol Cell. 2020. PMID: 32001105 Free article.

10

The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells.

Chi X, Nguyen D, Pemberton JM, Osterlund EJ, Liu Q, Brahmbhatt H, Zhang Z, Lin J, Leber B, Andrews DW. Chi X, et al. Elife. 2020 Jan 24;9:e44525. doi: 10.7554/eLife.44525. Elife. 2020. PMID: 31976859 Free PMC article.

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