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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2012 33
2013 82
2014 96
2015 98
2016 133
2017 167
2018 144
2019 162
2020 145
2021 82
2022 54
2023 50
2024 7

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1,159 results

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Page 1
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.
Hanan EJ, Braun MG, Heald RA, MacLeod C, Chan C, Clausen S, Edgar KA, Eigenbrot C, Elliott R, Endres N, Friedman LS, Gogol E, Gu XH, Thibodeau RH, Jackson PS, Kiefer JR, Knight JD, Nannini M, Narukulla R, Pace A, Pang J, Purkey HE, Salphati L, Sampath D, Schmidt S, Sideris S, Song K, Sujatha-Bhaskar S, Ultsch M, Wallweber H, Xin J, Yeap S, Young A, Zhong Y, Staben ST. Hanan EJ, et al. J Med Chem. 2022 Dec 22;65(24):16589-16621. doi: 10.1021/acs.jmedchem.2c01422. Epub 2022 Dec 1. J Med Chem. 2022. PMID: 36455032
Electric-field-stimulated protein mechanics.
Hekstra DR, White KI, Socolich MA, Henning RW, Šrajer V, Ranganathan R. Hekstra DR, et al. Nature. 2016 Dec 15;540(7633):400-405. doi: 10.1038/nature20571. Epub 2016 Dec 7. Nature. 2016. PMID: 27926732 Free PMC article.
Broadening a SARS-CoV-1-neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution.
Zhao F, Yuan M, Keating C, Shaabani N, Limbo O, Joyce C, Woehl J, Barman S, Burns A, Tran Q, Zhu X, Ricciardi M, Peng L, Smith J, Huang D, Briney B, Sok D, Nemazee D, Teijaro JR, Wilson IA, Burton DR, Jardine JG. Zhao F, et al. Sci Signal. 2023 Aug 15;16(798):eabk3516. doi: 10.1126/scisignal.abk3516. Epub 2023 Aug 15. Sci Signal. 2023. PMID: 37582161
Parallel molecular mechanisms for enzyme temperature adaptation.
Pinney MM, Mokhtari DA, Akiva E, Yabukarski F, Sanchez DM, Liang R, Doukov T, Martinez TJ, Babbitt PC, Herschlag D. Pinney MM, et al. Science. 2021 Mar 5;371(6533):eaay2784. doi: 10.1126/science.aay2784. Science. 2021. PMID: 33674467
Ancient plant-like terpene biosynthesis in corals.
Burkhardt I, de Rond T, Chen PY, Moore BS. Burkhardt I, et al. Nat Chem Biol. 2022 Jun;18(6):664-669. doi: 10.1038/s41589-022-01026-2. Epub 2022 May 23. Nat Chem Biol. 2022. PMID: 35606558 Free PMC article.
An ecophysiological explanation for manganese enrichment in rock varnish.
Lingappa UF, Yeager CM, Sharma A, Lanza NL, Morales DP, Xie G, Atencio AD, Chadwick GL, Monteverde DR, Magyar JS, Webb SM, Valentine JS, Hoffman BM, Fischer WW. Lingappa UF, et al. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2025188118. doi: 10.1073/pnas.2025188118. Epub 2021 Jun 14. Proc Natl Acad Sci U S A. 2021. PMID: 34161271 Free PMC article.
1,159 results