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Year | Number of Results |
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2024 | 2 |
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DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER.
Cell Metab. 2024 Mar 5;36(3):617-629.e7. doi: 10.1016/j.cmet.2024.01.011. Epub 2024 Feb 9.
Cell Metab. 2024.
PMID: 38340721
Free PMC article.
A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection.
Heisler DB, Johnson KA, Ma DH, Ohlson MB, Zhang L, Tran M, Corley CD, Abrams ME, McDonald JG, Schoggins JW, Alto NM, Radhakrishnan A.
Heisler DB, et al.
Elife. 2023 Jan 25;12:e83534. doi: 10.7554/eLife.83534.
Elife. 2023.
PMID: 36695568
Free PMC article.
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A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells.
Xu S, Smothers JC, Rye D, Endapally S, Chen H, Li S, Liang G, Kinnebrew M, Rohatgi R, Posner BA, Radhakrishnan A.
Xu S, et al.
Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2318024121. doi: 10.1073/pnas.2318024121. Epub 2024 Feb 8.
Proc Natl Acad Sci U S A. 2024.
PMID: 38330014
Free PMC article.
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