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CNS fibroblasts form a fibrotic scar in response to immune cell infiltration.
Dorrier CE, Aran D, Haenelt EA, Sheehy RN, Hoi KK, Pintarić L, Chen Y, Lizama CO, Cautivo KM, Weiner GA, Popko B, Fancy SPJ, Arnold TD, Daneman R. Dorrier CE, et al. Nat Neurosci. 2021 Feb;24(2):234-244. doi: 10.1038/s41593-020-00770-9. Epub 2021 Feb 1. Nat Neurosci. 2021. PMID: 33526922 Free PMC article.
Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module.
Munji RN, Soung AL, Weiner GA, Sohet F, Semple BD, Trivedi A, Gimlin K, Kotoda M, Korai M, Aydin S, Batugal A, Cabangcala AC, Schupp PG, Oldham MC, Hashimoto T, Noble-Haeusslein LJ, Daneman R. Munji RN, et al. Nat Neurosci. 2019 Nov;22(11):1892-1902. doi: 10.1038/s41593-019-0497-x. Epub 2019 Oct 14. Nat Neurosci. 2019. PMID: 31611708 Free PMC article.
Emerging roles for CNS fibroblasts in health, injury and disease.
Dorrier CE, Jones HE, Pintarić L, Siegenthaler JA, Daneman R. Dorrier CE, et al. Nat Rev Neurosci. 2022 Jan;23(1):23-34. doi: 10.1038/s41583-021-00525-w. Epub 2021 Oct 20. Nat Rev Neurosci. 2022. PMID: 34671105 Free PMC article. Review.
Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes.
Pulido RS, Munji RN, Chan TC, Quirk CR, Weiner GA, Weger BD, Rossi MJ, Elmsaouri S, Malfavon M, Deng A, Profaci CP, Blanchette M, Qian T, Foreman KL, Shusta EV, Gorman MR, Gachon F, Leutgeb S, Daneman R. Pulido RS, et al. Neuron. 2020 Dec 9;108(5):937-952.e7. doi: 10.1016/j.neuron.2020.09.002. Epub 2020 Sep 25. Neuron. 2020. PMID: 32979312 Free PMC article.