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Airway administration of OM-85, a bacterial lysate, blocks experimental asthma by targeting dendritic cells and the epithelium/IL-33/ILC2 axis.
Pivniouk V, Gimenes-Junior JA, Ezeh P, Michael A, Pivniouk O, Hahn S, VanLinden SR, Malone SP, Abidov A, Anderson D, Gozdz J, DeVries A, Martinez FD, Pasquali C, Vercelli D. Pivniouk V, et al. J Allergy Clin Immunol. 2022 Mar;149(3):943-956. doi: 10.1016/j.jaci.2021.09.013. Epub 2021 Sep 22. J Allergy Clin Immunol. 2022. PMID: 34560105 Free PMC article.
Asthma-protective agents in dust from traditional farm environments.
Marques Dos Santos M, Pivniouk V, Rankl B, Walker A, Pagani G, Hertkorn N, Schmitt-Kopplin P, Müller C, Bracher F, Merl-Pham J, Hauck SM, Schloter M, Michael AN, Anderson D, Honeker L, Gozdz J, Pivniouk O, Ober C, Holbreich M, Martinez FD, Snyder SA, von Mutius E, Vercelli D. Marques Dos Santos M, et al. J Allergy Clin Immunol. 2023 Sep;152(3):610-621. doi: 10.1016/j.jaci.2023.05.013. Epub 2023 Jun 2. J Allergy Clin Immunol. 2023. PMID: 37271318 Free article.
The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression.
Pivniouk V, Pivniouk O, DeVries A, Uhrlaub JL, Michael A, Pivniouk D, VanLinden SR, Conway MY, Hahn S, Malone SP, Ezeh P, Churko JM, Anderson D, Kraft M, Nikolich-Zugich J, Vercelli D. Pivniouk V, et al. J Allergy Clin Immunol. 2022 Mar;149(3):923-933.e6. doi: 10.1016/j.jaci.2021.11.019. Epub 2021 Dec 10. J Allergy Clin Immunol. 2022. PMID: 34902435 Free PMC article.
Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age.
Morin A, McKennan CG, Pedersen CT, Stokholm J, Chawes BL, Malby Schoos AM, Naughton KA, Thorsen J, Mortensen MS, Vercelli D, Trivedi U, Sørensen SJ, Bisgaard H, Nicolae DL, Bønnelykke K, Ober C. Morin A, et al. J Allergy Clin Immunol. 2020 Dec;146(6):1358-1366. doi: 10.1016/j.jaci.2020.07.005. Epub 2020 Jul 18. J Allergy Clin Immunol. 2020. PMID: 32693091 Free PMC article. Clinical Trial.