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Year Number of Results
2020 5
2021 5
2022 2
2023 2
2024 2

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15 results

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Page 1
A phase 2 biomarker-driven study of ruxolitinib demonstrates effectiveness of JAK/STAT targeting in T-cell lymphomas.
Moskowitz AJ, Ghione P, Jacobsen E, Ruan J, Schatz JH, Noor S, Myskowski P, Vardhana S, Ganesan N, Hancock H, Davey T, Perez L, Ryu S, Santarosa A, Dowd J, Obadi O, Pomerantz L, Yi N, Sohail S, Galasso N, Neuman R, Liotta B, Blouin W, Baik J, Geyer MB, Noy A, Straus D, Kumar P, Dogan A, Hollmann T, Drill E, Rademaker J, Schoder H, Inghirami G, Weinstock DM, Horwitz SM. Moskowitz AJ, et al. Blood. 2021 Dec 30;138(26):2828-2837. doi: 10.1182/blood.2021013379. Blood. 2021. PMID: 34653242 Free PMC article. Clinical Trial.
TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence.
Wu G, Yoshida N, Liu J, Zhang X, Xiong Y, Heavican-Foral TB, Mandato E, Liu H, Nelson GM, Yang L, Chen R, Donovan KA, Jones MK, Roshal M, Zhang Y, Xu R, Nirmal AJ, Jain S, Leahy C, Jones KL, Stevenson KE, Galasso N, Ganesan N, Chang T, Wu WC, Louissaint A, Debaize L, Yoon H, Dal Cin P, Chan WC, Ho Sui SJ, Ng SY, Feldman AL, Horwitz SM, Adelman K, Fischer ES, Chen CW, Weinstock DM, Brown M. Wu G, et al. Sci Transl Med. 2023 Sep 20;15(714):eadi7244. doi: 10.1126/scitranslmed.adi7244. Epub 2023 Sep 20. Sci Transl Med. 2023. PMID: 37729434 Free PMC article.
Signalling input from divergent pathways subverts B cell transformation.
Chan LN, Murakami MA, Robinson ME, Caeser R, Sadras T, Lee J, Cosgun KN, Kume K, Khairnar V, Xiao G, Ahmed MA, Aghania E, Deb G, Hurtz C, Shojaee S, Hong C, Pölönen P, Nix MA, Chen Z, Chen CW, Chen J, Vogt A, Heinäniemi M, Lohi O, Wiita AP, Izraeli S, Geng H, Weinstock DM, Müschen M. Chan LN, et al. Nature. 2020 Jul;583(7818):845-851. doi: 10.1038/s41586-020-2513-4. Epub 2020 Jul 22. Nature. 2020. PMID: 32699415 Free PMC article.
Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1.
Wu W, Nelson GM, Koch R, Donovan KA, Nowak RP, Heavican-Foral TB, Nirmal AJ, Liu H, Yang L, Duffy J, Powers F, Stevenson KE, Jones MK, Ng SY, Wu G, Jain S, Xu R, Amaka S, Trevisani C, Donaldson NL, Hagner PR, de Leval L, Gaulard P, Iqbal J, Thakurta A, Fischer ES, Adelman K, Weinstock DM. Wu W, et al. Blood. 2022 Mar 31;139(13):2024-2037. doi: 10.1182/blood.2021014701. Blood. 2022. PMID: 34936696 Free PMC article.
IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells.
Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. Lee J, et al. Nature. 2020 Dec;588(7838):491-497. doi: 10.1038/s41586-020-2884-6. Epub 2020 Nov 4. Nature. 2020. PMID: 33149299 Free PMC article.
Low-cost transcriptional diagnostic to accurately categorize lymphomas in low- and middle-income countries.
Valvert F, Silva O, Solórzano-Ortiz E, Puligandla M, Siliézar Tala MM, Guyon T, Dixon SL, López N, López F, Carías Alvarado CC, Terbrueggen R, Stevenson KE, Natkunam Y, Weinstock DM, Briercheck EL. Valvert F, et al. Blood Adv. 2021 May 25;5(10):2447-2455. doi: 10.1182/bloodadvances.2021004347. Blood Adv. 2021. PMID: 33988700 Free PMC article.
Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis.
Togami K, Chung SS, Madan V, Booth CAG, Kenyon CM, Cabal-Hierro L, Taylor J, Kim SS, Griffin GK, Ghandi M, Li J, Li YY, Angelot-Delettre F, Biichle S, Seiler M, Buonamici S, Lovitch SB, Louissaint A Jr, Morgan EA, Jardin F, Piccaluga PP, Weinstock DM, Hammerman PS, Yang H, Konopleva M, Pemmaraju N, Garnache-Ottou F, Abdel-Wahab O, Koeffler HP, Lane AA. Togami K, et al. Cancer Discov. 2022 Feb;12(2):522-541. doi: 10.1158/2159-8290.CD-20-1513. Epub 2021 Oct 6. Cancer Discov. 2022. PMID: 34615655 Free PMC article.
Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts.
Olesinski EA, Bhatia KS, Wang C, Pioso MS, Lin XX, Mamdouh AM, Ng SX, Sandhu V, Jasdanwala SS, Yilma B, Bohl S, Ryan JA, Malani D, Luskin MR, Kallioniemi O, Porkka K, Adamia S, Chng WJ, Osato M, Weinstock DM, Garcia JS, Letai A, Bhatt S. Olesinski EA, et al. Blood Cancer Discov. 2024 May 1;5(3):180-201. doi: 10.1158/2643-3230.BCD-24-0001. Blood Cancer Discov. 2024. PMID: 38442309
15 results