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Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7.
Saha M, Scerba MT, Shank NI, Hartman TL, Buchholz CA, Buckheit RW Jr, Durell SR, Appella DH. Saha M, et al. Among authors: appella dh. ChemMedChem. 2017 May 22;12(10):714-721. doi: 10.1002/cmdc.201700141. Epub 2017 Apr 25. ChemMedChem. 2017. PMID: 28395128 Free PMC article.
Inhibition of HIV Maturation via Selective Unfolding and Cross-Linking of Gag Polyprotein by a Mercaptobenzamide Acetylator.
Miller Jenkins LM, Paine EL, Deshmukh L, Nikolayevskiy H, Lyons GC, Scerba MT, George Rosenker K, Luecke HF, Louis JM, Chertova E, Gorelick RJ, Ott DE, Clore GM, Appella DH. Miller Jenkins LM, et al. Among authors: appella dh. J Am Chem Soc. 2019 May 22;141(20):8327-8338. doi: 10.1021/jacs.9b02743. Epub 2019 May 13. J Am Chem Soc. 2019. PMID: 31042030 Free PMC article.
Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer.
Miller Jenkins LM, Ott DE, Hayashi R, Coren LV, Wang D, Xu Q, Schito ML, Inman JK, Appella DH, Appella E. Miller Jenkins LM, et al. Among authors: appella dh, appella e. Nat Chem Biol. 2010 Dec;6(12):887-9. doi: 10.1038/nchembio.456. Epub 2010 Oct 17. Nat Chem Biol. 2010. PMID: 20953192 Free PMC article.
Preclinical evaluation of a mercaptobenzamide and its prodrug for NCp7-targeted inhibition of human immunodeficiency virus.
Hartman TL, Yang L, Helfrick AN, Hassink M, Shank NI, George Rosenker K, Scerba MT, Saha M, Hughes E, Wang AQ, Xu X, Gupta P, Buckheit RW Jr, Appella DH. Hartman TL, et al. Among authors: appella dh. Antiviral Res. 2016 Oct;134:216-225. doi: 10.1016/j.antiviral.2016.08.022. Epub 2016 Aug 26. Antiviral Res. 2016. PMID: 27568924 Free PMC article.
An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes.
Helmold Hait S, Hogge CJ, Rahman MA, Ko EJ, Hunegnaw R, Mushtaq Z, Enyindah-Asonye G, Hoang T, Miller Jenkins LM, Appella E, Appella DH, Robert-Guroff M. Helmold Hait S, et al. Among authors: appella dh, appella e. J Immunol. 2020 Jun 15;204(12):3315-3328. doi: 10.4049/jimmunol.2000165. Epub 2020 May 11. J Immunol. 2020. PMID: 32393514 Free PMC article.
Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication.
Wang D, Iera J, Baker H, Hogan P, Ptak R, Yang L, Hartman T, Buckheit RW Jr, Desjardins A, Yang A, Legault P, Yedavalli V, Jeang KT, Appella DH. Wang D, et al. Among authors: appella dh. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6893-7. doi: 10.1016/j.bmcl.2009.10.078. Epub 2009 Oct 23. Bioorg Med Chem Lett. 2009. PMID: 19896372 Free PMC article.
80 results