Dihydrofolate reductase: multiple conformations and alternative modes of substrate binding.
Birdsall B, Feeney J, Tendler SJ, Hammond SJ, Roberts GC.
Birdsall B, et al.
Biochemistry. 1989 Mar 7;28(5):2297-305. doi: 10.1021/bi00431a048.
Biochemistry. 1989.
PMID: 2524214
The complex of Lactobacillus casei dihydrofolate reductase with the substrate folate and the coenzyme NADP+ has been shown to exist in solution as a mixture of three slowly interconverting conformations whose proportions are pH-dependent [Birdsall, B., Gronenborn, A …
The complex of Lactobacillus casei dihydrofolate reductase with the substrate folate and the coenzyme NADP+ has been shown to exist in solut …