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Long-term codeine use is associated with depressive symptoms.
Romach MK, Sproule BA, Sellers EM, Somer G, Busto UE. Romach MK, et al. Among authors: busto ue. J Clin Psychopharmacol. 1999 Aug;19(4):373-6. doi: 10.1097/00004714-199908000-00015. J Clin Psychopharmacol. 1999. PMID: 10440467
Inhibition of cytochrome P450 2D6 modifies codeine abuse liability.
Kathiramalainathan K, Kaplan HL, Romach MK, Busto UE, Li NY, Säwe J, Tyndale RF, Sellers EM. Kathiramalainathan K, et al. Among authors: busto ue. J Clin Psychopharmacol. 2000 Aug;20(4):435-44. doi: 10.1097/00004714-200008000-00008. J Clin Psychopharmacol. 2000. PMID: 10917405 Clinical Trial.
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