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Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state.
Mergenthaler P, Kahl A, Kamitz A, van Laak V, Stohlmann K, Thomsen S, Klawitter H, Przesdzing I, Neeb L, Freyer D, Priller J, Collins TJ, Megow D, Dirnagl U, Andrews DW, Meisel A. Mergenthaler P, et al. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1518-23. doi: 10.1073/pnas.1108225109. Epub 2012 Jan 10. Proc Natl Acad Sci U S A. 2012. PMID: 22233811 Free PMC article.
Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells.
Sachlos E, Risueño RM, Laronde S, Shapovalova Z, Lee JH, Russell J, Malig M, McNicol JD, Fiebig-Comyn A, Graham M, Levadoux-Martin M, Lee JB, Giacomelli AO, Hassell JA, Fischer-Russell D, Trus MR, Foley R, Leber B, Xenocostas A, Brown ED, Collins TJ, Bhatia M. Sachlos E, et al. Cell. 2012 Jun 8;149(6):1284-97. doi: 10.1016/j.cell.2012.03.049. Epub 2012 May 24. Cell. 2012. PMID: 22632761 Free article.
Sam68 Allows Selective Targeting of Human Cancer Stem Cells.
Benoit YD, Mitchell RR, Risueño RM, Orlando L, Tanasijevic B, Boyd AL, Aslostovar L, Salci KR, Shapovalova Z, Russell J, Eguchi M, Golubeva D, Graham M, Xenocostas A, Trus MR, Foley R, Leber B, Collins TJ, Bhatia M. Benoit YD, et al. Cell Chem Biol. 2017 Jul 20;24(7):833-844.e9. doi: 10.1016/j.chembiol.2017.05.026. Epub 2017 Jun 22. Cell Chem Biol. 2017. PMID: 28648376 Free article.
Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche.
Boyd AL, Reid JC, Salci KR, Aslostovar L, Benoit YD, Shapovalova Z, Nakanishi M, Porras DP, Almakadi M, Campbell CJV, Jackson MF, Ross CA, Foley R, Leber B, Allan DS, Sabloff M, Xenocostas A, Collins TJ, Bhatia M. Boyd AL, et al. Nat Cell Biol. 2017 Nov;19(11):1336-1347. doi: 10.1038/ncb3625. Epub 2017 Oct 16. Nat Cell Biol. 2017. PMID: 29035359
1,483 results