Conklin BR - Search Results

1

Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair.

Wienert B, Nguyen DN, Guenther A, Feng SJ, Locke MN, Wyman SK, Shin J, Kazane KR, Gregory GL, Carter MAM, Wright F, Conklin BR, Marson A, Richardson CD, Corn JE. Wienert B, et al. Among authors: conklin br. Nat Commun. 2020 Apr 30;11(1):2109. doi: 10.1038/s41467-020-15845-1. Nat Commun. 2020. PMID: 32355159 Free PMC article.

2

Isolation of single-base genome-edited human iPS cells without antibiotic selection.

Miyaoka Y, Chan AH, Judge LM, Yoo J, Huang M, Nguyen TD, Lizarraga PP, So PL, Conklin BR. Miyaoka Y, et al. Among authors: conklin br. Nat Methods. 2014 Mar;11(3):291-3. doi: 10.1038/nmeth.2840. Epub 2014 Feb 9. Nat Methods. 2014. PMID: 24509632 Free PMC article.

3

Self-organizing human cardiac microchambers mediated by geometric confinement.

Ma Z, Wang J, Loskill P, Huebsch N, Koo S, Svedlund FL, Marks NC, Hua EW, Grigoropoulos CP, Conklin BR, Healy KE. Ma Z, et al. Among authors: conklin br. Nat Commun. 2015 Jul 14;6:7413. doi: 10.1038/ncomms8413. Nat Commun. 2015. PMID: 26172574 Free PMC article.

4

Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells.

Kime C, Mandegar MA, Srivastava D, Yamanaka S, Conklin BR, Rand TA. Kime C, et al. Among authors: conklin br. Curr Protoc Hum Genet. 2016 Jan 1;88:21.4.1-21.4.23. doi: 10.1002/0471142905.hg2104s88. Curr Protoc Hum Genet. 2016. PMID: 26724721 Free PMC article.

5

Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing.

Miyaoka Y, Berman JR, Cooper SB, Mayerl SJ, Chan AH, Zhang B, Karlin-Neumann GA, Conklin BR. Miyaoka Y, et al. Among authors: conklin br. Sci Rep. 2016 Mar 31;6:23549. doi: 10.1038/srep23549. Sci Rep. 2016. PMID: 27030102 Free PMC article.

6

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.

Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA. Nguyen DP, et al. Among authors: conklin br. Nat Commun. 2016 Jul 1;7:12009. doi: 10.1038/ncomms12009. Nat Commun. 2016. PMID: 27363581 Free PMC article.

7

Detection and Quantification of HDR and NHEJ Induced by Genome Editing at Endogenous Gene Loci Using Droplet Digital PCR.

Miyaoka Y, Mayerl SJ, Chan AH, Conklin BR. Miyaoka Y, et al. Among authors: conklin br. Methods Mol Biol. 2018;1768:349-362. doi: 10.1007/978-1-4939-7778-9_20. Methods Mol Biol. 2018. PMID: 29717453 Free PMC article.

8

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.

Wienert B, Wyman SK, Richardson CD, Yeh CD, Akcakaya P, Porritt MJ, Morlock M, Vu JT, Kazane KR, Watry HL, Judge LM, Conklin BR, Maresca M, Corn JE. Wienert B, et al. Among authors: conklin br. Science. 2019 Apr 19;364(6437):286-289. doi: 10.1126/science.aav9023. Epub 2019 Apr 18. Science. 2019. PMID: 31000663 Free PMC article.

9

CRISPR off-target detection with DISCOVER-seq.

Wienert B, Wyman SK, Yeh CD, Conklin BR, Corn JE. Wienert B, et al. Among authors: conklin br. Nat Protoc. 2020 May;15(5):1775-1799. doi: 10.1038/s41596-020-0309-5. Epub 2020 Apr 20. Nat Protoc. 2020. PMID: 32313254 Free PMC article.

10

Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits.

Federman AD, Conklin BR, Schrader KA, Reed RR, Bourne HR. Federman AD, et al. Among authors: conklin br. Nature. 1992 Mar 12;356(6365):159-61. doi: 10.1038/356159a0. Nature. 1992. PMID: 1312225

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