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Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair.
Wienert B, Nguyen DN, Guenther A, Feng SJ, Locke MN, Wyman SK, Shin J, Kazane KR, Gregory GL, Carter MAM, Wright F, Conklin BR, Marson A, Richardson CD, Corn JE. Wienert B, et al. Nat Commun. 2020 Apr 30;11(1):2109. doi: 10.1038/s41467-020-15845-1. Nat Commun. 2020. PMID: 32355159 Free PMC article.
SLC19A1 transports immunoreactive cyclic dinucleotides.
Luteijn RD, Zaver SA, Gowen BG, Wyman SK, Garelis NE, Onia L, McWhirter SM, Katibah GE, Corn JE, Woodward JJ, Raulet DH. Luteijn RD, et al. Nature. 2019 Sep;573(7774):434-438. doi: 10.1038/s41586-019-1553-0. Epub 2019 Sep 11. Nature. 2019. PMID: 31511694 Free PMC article.
Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.
Wienert B, Wyman SK, Richardson CD, Yeh CD, Akcakaya P, Porritt MJ, Morlock M, Vu JT, Kazane KR, Watry HL, Judge LM, Conklin BR, Maresca M, Corn JE. Wienert B, et al. Science. 2019 Apr 19;364(6437):286-289. doi: 10.1126/science.aav9023. Epub 2019 Apr 18. Science. 2019. PMID: 31000663 Free PMC article.