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Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency.
J Exp Med. 2024 Jun 3;221(6):e20231704. doi: 10.1084/jem.20231704. Epub 2024 Apr 18.
J Exp Med. 2024.
PMID: 38634869
Free PMC article.
Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes.
Wyatt RC, Hagopian WA, Roep BO, Patel KA, Resnick B, Dobbs R, Hudson M; EXE-T1D Consortium; De Franco E, Ellard S, Flanagan SE, Hattersley AT, Oram RA, Johnson MB.
Wyatt RC, et al.
Diabetologia. 2022 Jul;65(7):1179-1184. doi: 10.1007/s00125-022-05697-3. Epub 2022 Apr 30.
Diabetologia. 2022.
PMID: 35501400
Free PMC article.
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Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells.
Johnson MB, Patel KA, De Franco E, Hagopian W, Killian M, McDonald TJ, Tree TIM, Domingo-Vila C, Hudson M, Hammersley S, Dobbs R; EXE-T1D Consortium; Ellard S, Flanagan SE, Hattersley AT, Oram RA.
Johnson MB, et al.
Diabetologia. 2020 Dec;63(12):2605-2615. doi: 10.1007/s00125-020-05276-4. Epub 2020 Oct 8.
Diabetologia. 2020.
PMID: 33029656
Free PMC article.
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