Gustchina E - Search Results

1

Synergistic inhibition of HIV-1 envelope-mediated membrane fusion by inhibitors targeting the N and C-terminal heptad repeats of gp41.

Gustchina E, Louis JM, Bewley CA, Clore GM. Gustchina E, et al. J Mol Biol. 2006 Dec 1;364(3):283-9. doi: 10.1016/j.jmb.2006.09.017. Epub 2006 Sep 12. J Mol Biol. 2006. PMID: 17010381 Free PMC article.

2

Differential inhibition of HIV-1 and SIV envelope-mediated cell fusion by C34 peptides derived from the C-terminal heptad repeat of gp41 from diverse strains of HIV-1, HIV-2, and SIV.

Gustchina E, Hummer G, Bewley CA, Clore GM. Gustchina E, et al. J Med Chem. 2005 Apr 21;48(8):3036-44. doi: 10.1021/jm049026h. J Med Chem. 2005. PMID: 15828842

3

Characterization and HIV-1 fusion inhibitory properties of monoclonal Fabs obtained from a human non-immune phage library selected against diverse epitopes of the ectodomain of HIV-1 gp41.

Louis JM, Bewley CA, Gustchina E, Aniana A, Clore GM. Louis JM, et al. Among authors: gustchina e. J Mol Biol. 2005 Nov 11;353(5):945-51. doi: 10.1016/j.jmb.2005.09.044. Epub 2005 Sep 30. J Mol Biol. 2005. PMID: 16216270

4

A monoclonal Fab derived from a human nonimmune phage library reveals a new epitope on gp41 and neutralizes diverse human immunodeficiency virus type 1 strains.

Gustchina E, Louis JM, Lam SN, Bewley CA, Clore GM. Gustchina E, et al. J Virol. 2007 Dec;81(23):12946-53. doi: 10.1128/JVI.01260-07. Epub 2007 Sep 26. J Virol. 2007. PMID: 17898046 Free PMC article.

5

Sequestering of the prehairpin intermediate of gp41 by peptide N36Mut(e,g) potentiates the human immunodeficiency virus type 1 neutralizing activity of monoclonal antibodies directed against the N-terminal helical repeat of gp41.

Gustchina E, Bewley CA, Clore GM. Gustchina E, et al. J Virol. 2008 Oct;82(20):10032-41. doi: 10.1128/JVI.01050-08. Epub 2008 Jul 30. J Virol. 2008. PMID: 18667502 Free PMC article.

6

Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth.

Gustchina E, Louis JM, Frisch C, Ylera F, Lechner A, Bewley CA, Clore GM. Gustchina E, et al. Virology. 2009 Oct 10;393(1):112-9. doi: 10.1016/j.virol.2009.07.019. Epub 2009 Aug 19. Virology. 2009. PMID: 19695655 Free PMC article.

7

Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41.

Gustchina E, Li M, Louis JM, Anderson DE, Lloyd J, Frisch C, Bewley CA, Gustchina A, Wlodawer A, Clore GM. Gustchina E, et al. PLoS Pathog. 2010 Nov 11;6(11):e1001182. doi: 10.1371/journal.ppat.1001182. PLoS Pathog. 2010. PMID: 21085615 Free PMC article.

8

Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41.

Gustchina E, Li M, Ghirlando R, Schuck P, Louis JM, Pierson J, Rao P, Subramaniam S, Gustchina A, Clore GM, Wlodawer A. Gustchina E, et al. PLoS One. 2013 Nov 7;8(11):e78187. doi: 10.1371/journal.pone.0078187. eCollection 2013. PLoS One. 2013. PMID: 24244293 Free PMC article.

9

Mirabamides A-D, depsipeptides from the sponge Siliquariaspongia mirabilis that inhibit HIV-1 fusion.

Plaza A, Gustchina E, Baker HL, Kelly M, Bewley CA. Plaza A, et al. Among authors: gustchina e. J Nat Prod. 2007 Nov;70(11):1753-60. doi: 10.1021/np070306k. Epub 2007 Oct 27. J Nat Prod. 2007. PMID: 17963357

10

Solution structure of the monovalent lectin microvirin in complex with Man(alpha)(1-2)Man provides a basis for anti-HIV activity with low toxicity.

Shahzad-ul-Hussan S, Gustchina E, Ghirlando R, Clore GM, Bewley CA. Shahzad-ul-Hussan S, et al. Among authors: gustchina e. J Biol Chem. 2011 Jun 10;286(23):20788-96. doi: 10.1074/jbc.M111.232678. Epub 2011 Apr 6. J Biol Chem. 2011. PMID: 21471192 Free PMC article.

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