Huth JR - Search Results

1

The wing of the enhancer-binding domain of Mu phage transposase is flexible and is essential for efficient transposition.

Clubb RT, Mizuuchi M, Huth JR, Omichinski JG, Savilahti H, Mizuuchi K, Clore GM, Gronenborn AM. Clubb RT, et al. Among authors: huth jr. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1146-50. doi: 10.1073/pnas.93.3.1146. Proc Natl Acad Sci U S A. 1996. PMID: 8577730 Free PMC article.

2

Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex.

Werner MH, Huth JR, Gronenborn AM, Clore GM. Werner MH, et al. Among authors: huth jr. Cell. 1995 Jun 2;81(5):705-14. doi: 10.1016/0092-8674(95)90532-4. Cell. 1995. PMID: 7774012 Free article.

3

Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B.

Qin J, Clore GM, Kennedy WM, Huth JR, Gronenborn AM. Qin J, et al. Among authors: huth jr. Structure. 1995 Mar 15;3(3):289-97. doi: 10.1016/s0969-2126(01)00159-9. Structure. 1995. PMID: 7788295 Free article.

4

Molecular determinants of mammmalian sex.

Werner MH, Huth JR, Gronenborn AM, Clore GM. Werner MH, et al. Among authors: huth jr. Trends Biochem Sci. 1996 Aug;21(8):302-8. Trends Biochem Sci. 1996. PMID: 8772384 Review.

5

The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif.

Huth JR, Bewley CA, Nissen MS, Evans JN, Reeves R, Gronenborn AM, Clore GM. Huth JR, et al. Nat Struct Biol. 1997 Aug;4(8):657-65. doi: 10.1038/nsb0897-657. Nat Struct Biol. 1997. PMID: 9253416

6

Design of an expression system for detecting folded protein domains and mapping macromolecular interactions by NMR.

Huth JR, Bewley CA, Jackson BM, Hinnebusch AG, Clore GM, Gronenborn AM. Huth JR, et al. Protein Sci. 1997 Nov;6(11):2359-64. doi: 10.1002/pro.5560061109. Protein Sci. 1997. PMID: 9385638 Free PMC article.

7

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

Huth JR, Olejniczak ET, Mendoza R, Liang H, Harris EA, Lupher ML Jr, Wilson AE, Fesik SW, Staunton DE. Huth JR, et al. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5231-6. doi: 10.1073/pnas.97.10.5231. Proc Natl Acad Sci U S A. 2000. PMID: 10805782 Free PMC article.

8

NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter.

Huth JR, Yu L, Collins I, Mack J, Mendoza R, Isaac B, Braddock DT, Muchmore SW, Comess KM, Fesik SW, Clore GM, Levens D, Hajduk PJ. Huth JR, et al. J Med Chem. 2004 Sep 23;47(20):4851-7. doi: 10.1021/jm0497803. J Med Chem. 2004. PMID: 15369388

9

Druggability indices for protein targets derived from NMR-based screening data.

Hajduk PJ, Huth JR, Fesik SW. Hajduk PJ, et al. Among authors: huth jr. J Med Chem. 2005 Apr 7;48(7):2518-25. doi: 10.1021/jm049131r. J Med Chem. 2005. PMID: 15801841

10

Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.

Petros AM, Huth JR, Oost T, Park CM, Ding H, Wang X, Zhang H, Nimmer P, Mendoza R, Sun C, Mack J, Walter K, Dorwin S, Gramling E, Ladror U, Rosenberg SH, Elmore SW, Fesik SW, Hajduk PJ. Petros AM, et al. Among authors: huth jr. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6587-91. doi: 10.1016/j.bmcl.2010.09.033. Epub 2010 Sep 15. Bioorg Med Chem Lett. 2010. PMID: 20870405

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