Madden Z - Search Results

1

Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway.

Zhu Y, Shan X, Safarpour F, Erro Go N, Li N, Shan A, Huang MC, Deen M, Holicek V, Ashmus R, Madden Z, Gorski S, Silverman MA, Vocadlo DJ. Zhu Y, et al. Among authors: madden z. ACS Chem Neurosci. 2018 Jun 20;9(6):1366-1379. doi: 10.1021/acschemneuro.8b00015. Epub 2018 Mar 5. ACS Chem Neurosci. 2018. PMID: 29460617

2

Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter.

Zhu Y, Liu TW, Madden Z, Yuzwa SA, Murray K, Cecioni S, Zachara N, Vocadlo DJ. Zhu Y, et al. Among authors: madden z. J Mol Cell Biol. 2016 Feb;8(1):2-16. doi: 10.1093/jmcb/mjv033. Epub 2015 Jun 1. J Mol Cell Biol. 2016. PMID: 26031751 Free PMC article.

3

Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications.

González-Cuesta M, Sidhu P, Ashmus RA, Males A, Proceviat C, Madden Z, Rogalski JC, Busmann JA, Foster LJ, García Fernández JM, Davies GJ, Ortiz Mellet C, Vocadlo DJ. González-Cuesta M, et al. Among authors: madden z. J Am Chem Soc. 2022 Jan 19;144(2):832-844. doi: 10.1021/jacs.1c10504. Epub 2022 Jan 5. J Am Chem Soc. 2022. PMID: 34985906

4

Chemoproteomic identification of CO₂-dependent lysine carboxylation in proteins.

King DT, Zhu S, Hardie DB, Serrano-Negrón JE, Madden Z, Kolappan S, Vocadlo DJ. King DT, et al. Among authors: madden z. Nat Chem Biol. 2022 Jul;18(7):782-791. doi: 10.1038/s41589-022-01043-1. Epub 2022 Jun 16. Nat Chem Biol. 2022. PMID: 35710617

5

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa.

Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA. Ho LA, et al. Among authors: madden z. Chem Commun (Camb). 2018 Sep 25;54(75):10630-10633. doi: 10.1039/c8cc05281f. Epub 2018 Sep 4. Chem Commun (Camb). 2018. PMID: 30178799

6

Direct One-Step Fluorescent Labeling of O-GlcNAc-Modified Proteins in Live Cells Using Metabolic Intermediates.

Tan HY, Eskandari R, Shen D, Zhu Y, Liu TW, Willems LI, Alteen MG, Madden Z, Vocadlo DJ. Tan HY, et al. Among authors: madden z. J Am Chem Soc. 2018 Nov 14;140(45):15300-15308. doi: 10.1021/jacs.8b08260. Epub 2018 Oct 22. J Am Chem Soc. 2018. PMID: 30296064 Free article.

7

Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors.

Bouquet J, Auberger N, Ashmus R, King D, Bordes A, Fontelle N, Nakagawa S, Madden Z, Proceviat C, Kato A, Désiré J, Vocadlo DJ, Blériot Y. Bouquet J, et al. Among authors: madden z. Org Biomol Chem. 2022 Jan 19;20(3):619-629. doi: 10.1039/d1ob02280f. Org Biomol Chem. 2022. PMID: 34940771

8

HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition.

Magee KE, Madden Z, Young EC. Magee KE, et al. Among authors: madden z. J Membr Biol. 2015 Dec;248(6):1043-60. doi: 10.1007/s00232-015-9816-7. Epub 2015 Jun 30. J Membr Biol. 2015. PMID: 26123597

9

Sensitivity of HCN channel deactivation to cAMP is amplified by an S4 mutation combined with activation mode shift.

Wicks NL, Chan KS, Madden Z, Santoro B, Young EC. Wicks NL, et al. Among authors: madden z. Pflugers Arch. 2009 Sep;458(5):877-89. doi: 10.1007/s00424-009-0687-6. Epub 2009 Jun 21. Pflugers Arch. 2009. PMID: 19544068

10

Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.

Wicks NL, Wong T, Sun J, Madden Z, Young EC. Wicks NL, et al. Among authors: madden z. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):609-14. doi: 10.1073/pnas.1012750108. Epub 2010 Dec 27. Proc Natl Acad Sci U S A. 2011. PMID: 21187420 Free PMC article.

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