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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.
Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG. Bomfim TR, et al. Among authors: mcclean pl. J Clin Invest. 2012 Apr;122(4):1339-53. doi: 10.1172/JCI57256. J Clin Invest. 2012. PMID: 22476196 Free PMC article.
The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease.
Long-Smith CM, Manning S, McClean PL, Coakley MF, O'Halloran DJ, Holscher C, O'Neill C. Long-Smith CM, et al. Among authors: mcclean pl. Neuromolecular Med. 2013 Mar;15(1):102-14. doi: 10.1007/s12017-012-8199-5. Epub 2012 Sep 21. Neuromolecular Med. 2013. PMID: 23011726
A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease.
Parthsarathy V, McClean PL, Hölscher C, Taylor M, Tinker C, Jones G, Kolosov O, Salvati E, Gregori M, Masserini M, Allsop D. Parthsarathy V, et al. Among authors: mcclean pl. PLoS One. 2013;8(1):e54769. doi: 10.1371/journal.pone.0054769. Epub 2013 Jan 31. PLoS One. 2013. PMID: 23382963 Free PMC article.
44 results