Oost TK - Search Results

1

Discovery of aminoglycoside mimetics by NMR-based screening of Escherichia coli A-site RNA.

Yu L, Oost TK, Schkeryantz JM, Yang J, Janowick D, Fesik SW. Yu L, et al. Among authors: oost tk. J Am Chem Soc. 2003 Apr 16;125(15):4444-50. doi: 10.1021/ja021354o. J Am Chem Soc. 2003. PMID: 12683814

2

Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.

Petros AM, Huth JR, Oost T, Park CM, Ding H, Wang X, Zhang H, Nimmer P, Mendoza R, Sun C, Mack J, Walter K, Dorwin S, Gramling E, Ladror U, Rosenberg SH, Elmore SW, Fesik SW, Hajduk PJ. Petros AM, et al. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6587-91. doi: 10.1016/j.bmcl.2010.09.033. Epub 2010 Sep 15. Bioorg Med Chem Lett. 2010. PMID: 20870405

3

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.

Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Ding H, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Tomaselli KJ, Zou H, Fesik SW. Oost TK, et al. J Med Chem. 2004 Aug 26;47(18):4417-26. doi: 10.1021/jm040037k. J Med Chem. 2004. PMID: 15317454

4

Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.

Wendt MD, Shen W, Kunzer A, McClellan WJ, Bruncko M, Oost TK, Ding H, Joseph MK, Zhang H, Nimmer PM, Ng SC, Shoemaker AR, Petros AM, Oleksijew A, Marsh K, Bauch J, Oltersdorf T, Belli BA, Martineau D, Fesik SW, Rosenberg SH, Elmore SW. Wendt MD, et al. Among authors: oost tk. J Med Chem. 2006 Feb 9;49(3):1165-81. doi: 10.1021/jm050754u. J Med Chem. 2006. PMID: 16451081

5

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.

Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW. Liu Z, et al. Nature. 2000 Dec 21-28;408(6815):1004-8. doi: 10.1038/35050006. Nature. 2000. PMID: 11140637

6

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.

Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC, Nimmer PM, Oltersdorf T, Park CM, Petros AM, Shoemaker AR, Song X, Wang X, Wendt MD, Zhang H, Fesik SW, Rosenberg SH, Elmore SW. Bruncko M, et al. Among authors: oost tk. J Med Chem. 2007 Feb 22;50(4):641-62. doi: 10.1021/jm061152t. Epub 2007 Jan 26. J Med Chem. 2007. PMID: 17256834

7

Potent, selective inhibitors of protein tyrosine phosphatase 1B.

Xin Z, Oost TK, Abad-Zapatero C, Hajduk PJ, Pei Z, Szczepankiewicz BG, Hutchins CW, Ballaron SJ, Stashko MA, Lubben T, Trevillyan JM, Jirousek MR, Liu G. Xin Z, et al. Among authors: oost tk. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1887-90. doi: 10.1016/s0960-894x(03)00302-0. Bioorg Med Chem Lett. 2003. PMID: 12749891

8

Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties.

Oost T, Backfisch G, Bhowmik S, van Gaalen MM, Geneste H, Hornberger W, Lubisch W, Netz A, Unger L, Wernet W. Oost T, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3828-31. doi: 10.1016/j.bmcl.2011.03.012. Epub 2011 Mar 6. Bioorg Med Chem Lett. 2011. PMID: 21605973

9

Novel, potent, selective and brain penetrant vasopressin 1b receptor antagonists.

Geneste H, Bhowmik S, van Gaalen MM, Hornberger W, Hutchins CW, Netz A, Oost T, Unger L. Geneste H, et al. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3260-3264. doi: 10.1016/j.bmcl.2018.07.043. Epub 2018 Jul 31. Bioorg Med Chem Lett. 2018. PMID: 30098866

10

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908.

Oost T, Heckel A, Kley JT, Lehmann T, Müller S, Roth GJ, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Maier GM, Markert M, Thomas L, Stenkamp D. Oost T, et al. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3275-80. doi: 10.1016/j.bmcl.2015.05.065. Epub 2015 May 29. Bioorg Med Chem Lett. 2015. PMID: 26105194

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