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Discovery of 7-aminophenanthridin-6-one as a new scaffold for matrix metalloproteinase inhibitors with multitarget neuroprotective activity.
Rocchi D, Blázquez-Barbadillo C, Agamennone M, Laghezza A, Tortorella P, Vicente-Zurdo D, Rosales-Conrado N, Moyano P, Pino JD, González JF, Menéndez JC. Rocchi D, et al. Among authors: pino jd. Eur J Med Chem. 2021 Jan 15;210:113061. doi: 10.1016/j.ejmech.2020.113061. Epub 2020 Nov 30. Eur J Med Chem. 2021. PMID: 33310289
Single and repeated bisphenol A treatment induces ROS, Aβ and hyperphosphorylated-tau accumulation, and insulin pathways disruption, through HDAC2 and PTP1B overexpression, leading to SN56 cholinergic apoptotic cell death.
Flores A, Moyano P, Sola E, García JM, García J, Anadon MJ, Frejo MT, Naval MV, Fernadez MC, Pino JD. Flores A, et al. Among authors: pino jd. Food Chem Toxicol. 2022 Dec;170:113500. doi: 10.1016/j.fct.2022.113500. Epub 2022 Oct 29. Food Chem Toxicol. 2022. PMID: 36374790
17 results