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Most large structural variants in cancer genomes can be detected without long reads.
Choo ZN, Behr JM, Deshpande A, Hadi K, Yao X, Tian H, Takai K, Zakusilo G, Rosiene J, Da Cruz Paula A, Weigelt B, Setton J, Riaz N, Powell SN, Busam K, Shoushtari AN, Ariyan C, Reis-Filho J, de Lange T, Imieliński M. Choo ZN, et al. Nat Genet. 2023 Dec;55(12):2139-2148. doi: 10.1038/s41588-023-01540-6. Epub 2023 Nov 9. Nat Genet. 2023. PMID: 37945902 Free PMC article.
CST/Polα/primase-mediated fill-in synthesis at DSBs.
Mirman Z, Cai S, de Lange T. Mirman Z, et al. Cell Cycle. 2023 Feb;22(4):379-389. doi: 10.1080/15384101.2022.2123886. Epub 2022 Oct 7. Cell Cycle. 2023. PMID: 36205622 Free PMC article.
Shelterin is a dimeric complex with extensive structural heterogeneity.
Zinder JC, Olinares PDB, Svetlov V, Bush MW, Nudler E, Chait BT, Walz T, de Lange T. Zinder JC, et al. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2201662119. doi: 10.1073/pnas.2201662119. Epub 2022 Jul 26. Proc Natl Acad Sci U S A. 2022. PMID: 35881804 Free PMC article.
24 results