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Physics-driven structural docking and protein language models accelerate antibody screening and design for broad-spectrum antiviral therapy.
Almubarak HF, Tan W, Hoffmann AD, Wei J, El-Shennawy L, Squires JR, Sun Y, Dashzeveg NK, Simonton B, Jia Y, Iyer R, Xu Y, Nicolaescu V, Elli D, Randall GC, Schipma MJ, Swaminathan S, Ison MG, Liu H, Fang D, Shen Y. Almubarak HF, et al. Among authors: simonton b. bioRxiv [Preprint]. 2024 Mar 4:2024.03.01.582176. doi: 10.1101/2024.03.01.582176. bioRxiv. 2024. PMID: 38496411 Free PMC article. Preprint.
Epigenetic dysregulation in Alzheimer's disease peripheral immunity.
Ramakrishnan A, Piehl N, Simonton B, Parikh M, Zhang Z, Teregulova V, van Olst L, Gate D. Ramakrishnan A, et al. Among authors: simonton b. Neuron. 2024 Apr 17;112(8):1235-1248.e5. doi: 10.1016/j.neuron.2024.01.013. Epub 2024 Feb 9. Neuron. 2024. PMID: 38340719
Scalable genetic screening for regulatory circuits using compressed Perturb-seq.
Yao D, Binan L, Bezney J, Simonton B, Freedman J, Frangieh CJ, Dey K, Geiger-Schuller K, Eraslan B, Gusev A, Regev A, Cleary B. Yao D, et al. Among authors: simonton b. Nat Biotechnol. 2023 Oct 23:10.1038/s41587-023-01964-9. doi: 10.1038/s41587-023-01964-9. Online ahead of print. Nat Biotechnol. 2023. PMID: 37872410
Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment.
Piehl N, van Olst L, Ramakrishnan A, Teregulova V, Simonton B, Zhang Z, Tapp E, Channappa D, Oh H, Losada PM, Rutledge J, Trelle AN, Mormino EC, Elahi F, Galasko DR, Henderson VW, Wagner AD, Wyss-Coray T, Gate D. Piehl N, et al. Among authors: simonton b. Cell. 2022 Dec 22;185(26):5028-5039.e13. doi: 10.1016/j.cell.2022.11.019. Epub 2022 Dec 13. Cell. 2022. PMID: 36516855 Free PMC article.
Compressed sensing for highly efficient imaging transcriptomics.
Cleary B, Simonton B, Bezney J, Murray E, Alam S, Sinha A, Habibi E, Marshall J, Lander ES, Chen F, Regev A. Cleary B, et al. Among authors: simonton b. Nat Biotechnol. 2021 Aug;39(8):936-942. doi: 10.1038/s41587-021-00883-x. Epub 2021 Apr 15. Nat Biotechnol. 2021. PMID: 33859401 Free PMC article.
13 results