Zhu Y - Search Results

1

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.

Yuzwa SA, Shan X, Jones BA, Zhao G, Woodward ML, Li X, Zhu Y, McEachern EJ, Silverman MA, Watson NV, Gong CX, Vocadlo DJ. Yuzwa SA, et al. Among authors: zhu y. Mol Neurodegener. 2014 Oct 26;9:42. doi: 10.1186/1750-1326-9-42. Mol Neurodegener. 2014. PMID: 25344697 Free PMC article.

2

The emerging link between O-GlcNAc and Alzheimer disease.

Zhu Y, Shan X, Yuzwa SA, Vocadlo DJ. Zhu Y, et al. J Biol Chem. 2014 Dec 12;289(50):34472-81. doi: 10.1074/jbc.R114.601351. Epub 2014 Oct 21. J Biol Chem. 2014. PMID: 25336656 Free PMC article. Review.

3

O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains.

Zhu Y, Liu TW, Cecioni S, Eskandari R, Zandberg WF, Vocadlo DJ. Zhu Y, et al. Nat Chem Biol. 2015 May;11(5):319-25. doi: 10.1038/nchembio.1774. Epub 2015 Mar 16. Nat Chem Biol. 2015. PMID: 25774941

4

Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter.

Zhu Y, Liu TW, Madden Z, Yuzwa SA, Murray K, Cecioni S, Zachara N, Vocadlo DJ. Zhu Y, et al. J Mol Cell Biol. 2016 Feb;8(1):2-16. doi: 10.1093/jmcb/mjv033. Epub 2015 Jun 1. J Mol Cell Biol. 2016. PMID: 26031751 Free PMC article.

5

Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose.

Shen DL, Liu TW, Zandberg W, Clark T, Eskandari R, Alteen MG, Tan HY, Zhu Y, Cecioni S, Vocadlo D. Shen DL, et al. Among authors: zhu y. ACS Chem Biol. 2017 Jan 20;12(1):206-213. doi: 10.1021/acschembio.6b00876. Epub 2016 Dec 9. ACS Chem Biol. 2017. PMID: 27935279

6

Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway.

Zhu Y, Shan X, Safarpour F, Erro Go N, Li N, Shan A, Huang MC, Deen M, Holicek V, Ashmus R, Madden Z, Gorski S, Silverman MA, Vocadlo DJ. Zhu Y, et al. ACS Chem Neurosci. 2018 Jun 20;9(6):1366-1379. doi: 10.1021/acschemneuro.8b00015. Epub 2018 Mar 5. ACS Chem Neurosci. 2018. PMID: 29460617

7

Direct One-Step Fluorescent Labeling of O-GlcNAc-Modified Proteins in Live Cells Using Metabolic Intermediates.

Tan HY, Eskandari R, Shen D, Zhu Y, Liu TW, Willems LI, Alteen MG, Madden Z, Vocadlo DJ. Tan HY, et al. Among authors: zhu y. J Am Chem Soc. 2018 Nov 14;140(45):15300-15308. doi: 10.1021/jacs.8b08260. Epub 2018 Oct 22. J Am Chem Soc. 2018. PMID: 30296064 Free article.

8

Tandem Bioorthogonal Labeling Uncovers Endogenous Cotranslationally O-GlcNAc Modified Nascent Proteins.

Zhu Y, Willems LI, Salas D, Cecioni S, Wu WB, Foster LJ, Vocadlo DJ. Zhu Y, et al. J Am Chem Soc. 2020 Sep 16;142(37):15729-15739. doi: 10.1021/jacs.0c04121. Epub 2020 Sep 1. J Am Chem Soc. 2020. PMID: 32870666 Free article.

9

Thermal Proteome Profiling Reveals the O-GlcNAc-Dependent Meltome.

King DT, Serrano-Negrón JE, Zhu Y, Moore CL, Shoulders MD, Foster LJ, Vocadlo DJ. King DT, et al. Among authors: zhu y. J Am Chem Soc. 2022 Mar 9;144(9):3833-3842. doi: 10.1021/jacs.1c10621. Epub 2022 Mar 1. J Am Chem Soc. 2022. PMID: 35230102 Free PMC article.

10

A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells.

Deen MC, Zhu Y, Gros C, Na N, Gilormini PA, Shen DL, Bhosale S, Anastasi N, Wang R, Shan X, Harde E, Jagasia R, Lynn FC, Vocadlo DJ. Deen MC, et al. Among authors: zhu y. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2200553119. doi: 10.1073/pnas.2200553119. Epub 2022 Jul 12. Proc Natl Acad Sci U S A. 2022. PMID: 35858317 Free PMC article.

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