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Fragment-based lead discovery: challenges and opportunities.
Sun C, Petros AM, Hajduk PJ. Sun C, et al. Among authors: petros am. J Comput Aided Mol Des. 2011 Jul;25(7):607-10. doi: 10.1007/s10822-011-9451-z. Epub 2011 Jul 6. J Comput Aided Mol Des. 2011. PMID: 21732249
Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.
Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET. Huang Q, et al. Among authors: petros am. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3428-33. doi: 10.1073/pnas.062525799. Proc Natl Acad Sci U S A. 2002. PMID: 11904405 Free PMC article.
Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
Wendt MD, Shen W, Kunzer A, McClellan WJ, Bruncko M, Oost TK, Ding H, Joseph MK, Zhang H, Nimmer PM, Ng SC, Shoemaker AR, Petros AM, Oleksijew A, Marsh K, Bauch J, Oltersdorf T, Belli BA, Martineau D, Fesik SW, Rosenberg SH, Elmore SW. Wendt MD, et al. Among authors: petros am. J Med Chem. 2006 Feb 9;49(3):1165-81. doi: 10.1021/jm050754u. J Med Chem. 2006. PMID: 16451081
Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
Huth JR, Park C, Petros AM, Kunzer AR, Wendt MD, Wang X, Lynch CL, Mack JC, Swift KM, Judge RA, Chen J, Richardson PL, Jin S, Tahir SK, Matayoshi ED, Dorwin SA, Ladror US, Severin JM, Walter KA, Bartley DM, Fesik SW, Elmore SW, Hajduk PJ. Huth JR, et al. Among authors: petros am. Chem Biol Drug Des. 2007 Jul;70(1):1-12. doi: 10.1111/j.1747-0285.2007.00535.x. Chem Biol Drug Des. 2007. PMID: 17630989
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
Petros AM, Huth JR, Oost T, Park CM, Ding H, Wang X, Zhang H, Nimmer P, Mendoza R, Sun C, Mack J, Walter K, Dorwin S, Gramling E, Ladror U, Rosenberg SH, Elmore SW, Fesik SW, Hajduk PJ. Petros AM, et al. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6587-91. doi: 10.1016/j.bmcl.2010.09.033. Epub 2010 Sep 15. Bioorg Med Chem Lett. 2010. PMID: 20870405
70 results