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High activity and stability of hammerhead ribozymes containing 2'-modified pyrimidine nucleosides and phosphorothioates.
Heidenreich O, Benseler F, Fahrenholz A, Eckstein F. Heidenreich O, et al. J Biol Chem. 1994 Jan 21;269(3):2131-8. J Biol Chem. 1994. PMID: 8294467 Free article.
Previous studies had shown that substitution of all pyrimidine nucleosides by their 2'-fluoro analogs led to an 8-fold decrease in catalytic efficiency in the cleavage reaction compared to the unmodified ribozyme (Heidenreich, O., and Eckstein, F. (1992) J. Biol. Ch …
Previous studies had shown that substitution of all pyrimidine nucleosides by their 2'-fluoro analogs led to an 8-fold decrease in catalytic …
Ribozyme-mediated RNA degradation in nuclei suspension.
Heidenreich O, Kang SH, Brown DA, Xu X, Swiderski P, Rossi JJ, Eckstein F, Nerenberg M. Heidenreich O, et al. Nucleic Acids Res. 1995 Jun 25;23(12):2223-8. doi: 10.1093/nar/23.12.2223. Nucleic Acids Res. 1995. PMID: 7610051 Free PMC article.
Cleavage of AML1/MTG8 by asymmetric hammerhead ribozymes.
Szyrach M, Münchberg FE, Riehle H, Nordheim A, Krauter J, Nagel S, Heil G, Heidenreich O. Szyrach M, et al. Among authors: heidenreich o. Eur J Biochem. 2001 Jun;268(12):3550-7. doi: 10.1046/j.1432-1327.2001.02259.x. Eur J Biochem. 2001. PMID: 11422386 Free article.
215 results