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A small step towards an important goal: fragment screen of the c-di-AMP-synthesizing enzyme CdaA.
Acta Crystallogr D Struct Biol. 2024 May 1;80(Pt 5):350-361. doi: 10.1107/S205979832400336X. Epub 2024 Apr 29.
Acta Crystallogr D Struct Biol. 2024.
PMID: 38682668
Free PMC article.
Crystal structures of the c-di-AMP-synthesizing enzyme CdaA.
Heidemann JL, Neumann P, Dickmanns A, Ficner R.
Heidemann JL, et al.
J Biol Chem. 2019 Jul 5;294(27):10463-10470. doi: 10.1074/jbc.RA119.009246. Epub 2019 May 22.
J Biol Chem. 2019.
PMID: 31118276
Free PMC article.
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Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria.
Commichau FM, Heidemann JL, Ficner R, Stülke J.
Commichau FM, et al. Among authors: heidemann jl.
J Bacteriol. 2018 Dec 7;201(1):e00462-18. doi: 10.1128/JB.00462-18. Print 2019 Jan 1.
J Bacteriol. 2018.
PMID: 30224435
Free PMC article.
Review.
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A meet-up of two second messengers: the c-di-AMP receptor DarB controls (p)ppGpp synthesis in Bacillus subtilis.
Krüger L, Herzberg C, Wicke D, Bähre H, Heidemann JL, Dickmanns A, Schmitt K, Ficner R, Stülke J.
Krüger L, et al. Among authors: heidemann jl.
Nat Commun. 2021 Feb 22;12(1):1210. doi: 10.1038/s41467-021-21306-0.
Nat Commun. 2021.
PMID: 33619274
Free PMC article.
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Structural basis for c-di-AMP-dependent regulation of the bacterial stringent response by receptor protein DarB.
Heidemann JL, Neumann P, Krüger L, Wicke D, Vinhoven L, Linden A, Dickmanns A, Stülke J, Urlaub H, Ficner R.
Heidemann JL, et al.
J Biol Chem. 2022 Jul;298(7):102144. doi: 10.1016/j.jbc.2022.102144. Epub 2022 Jun 15.
J Biol Chem. 2022.
PMID: 35714772
Free PMC article.
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An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes.
Gibhardt J, Heidemann JL, Bremenkamp R, Rosenberg J, Seifert R, Kaever V, Ficner R, Commichau FM.
Gibhardt J, et al. Among authors: heidemann jl.
Environ Microbiol. 2020 Jul;22(7):2771-2791. doi: 10.1111/1462-2920.15008. Epub 2020 Apr 21.
Environ Microbiol. 2020.
PMID: 32250026
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