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ABT-299, a potent antagonist of platelet activating factor.
Summers JB, Albert DH, Davidsen SK, Conway RG, Holms JH, Magoc TJ, Luo G, Tapang P, Rhein DA, Carter GW. Summers JB, et al. Among authors: holms jh. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:475-7. Adv Prostaglandin Thromboxane Leukot Res. 1995. PMID: 7732895 No abstract available.
Discovery and characterization of the potent, selective and orally bioavailable MMP inhibitor ABT-770.
Curtin ML, Florjancic AS, Heyman HR, Michaelides MR, Garland RB, Holms JH, Steinman DH, Dellaria JF, Gong J, Wada CK, Guo Y, Elmore IB, Tapang P, Albert DH, Magoc TJ, Marcotte PA, Bouska JJ, Goodfellow CL, Bauch JL, Marsh KC, Morgan DW, Davidsen SK. Curtin ML, et al. Among authors: holms jh. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1557-60. doi: 10.1016/s0960-894x(01)00032-4. Bioorg Med Chem Lett. 2001. PMID: 11412980
Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors.
Wada CK, Holms JH, Curtin ML, Dai Y, Florjancic AS, Garland RB, Guo Y, Heyman HR, Stacey JR, Steinman DH, Albert DH, Bouska JJ, Elmore IN, Goodfellow CL, Marcotte PA, Tapang P, Morgan DW, Michaelides MR, Davidsen SK. Wada CK, et al. Among authors: holms jh. J Med Chem. 2002 Jan 3;45(1):219-32. doi: 10.1021/jm0103920. J Med Chem. 2002. PMID: 11754593
Alpha-keto amides as inhibitors of histone deacetylase.
Wada CK, Frey RR, Ji Z, Curtin ML, Garland RB, Holms JH, Li J, Pease LJ, Guo J, Glaser KB, Marcotte PA, Richardson PL, Murphy SS, Bouska JJ, Tapang P, Magoc TJ, Albert DH, Davidsen SK, Michaelides MR. Wada CK, et al. Among authors: holms jh. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3331-5. doi: 10.1016/s0960-894x(03)00685-1. Bioorg Med Chem Lett. 2003. PMID: 12951120
21 results