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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.
Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG. Bomfim TR, et al. Among authors: houzel jc. J Clin Invest. 2012 Apr;122(4):1339-53. doi: 10.1172/JCI57256. J Clin Invest. 2012. PMID: 22476196 Free PMC article.
Protein kinase C activity regulates D-serine availability in the brain.
Vargas-Lopes C, Madeira C, Kahn SA, Albino do Couto I, Bado P, Houzel JC, De Miranda J, de Freitas MS, Ferreira ST, Panizzutti R. Vargas-Lopes C, et al. Among authors: houzel jc. J Neurochem. 2011 Jan;116(2):281-90. doi: 10.1111/j.1471-4159.2010.07102.x. J Neurochem. 2011. PMID: 21070240 Free article.
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.
Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG. Lourenco MV, et al. Among authors: houzel jc. Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002. Cell Metab. 2013. PMID: 24315369 Free article.
Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.
Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG. Forny-Germano L, et al. Among authors: houzel jc. J Neurosci. 2014 Oct 8;34(41):13629-43. doi: 10.1523/JNEUROSCI.1353-14.2014. J Neurosci. 2014. PMID: 25297091 Free PMC article.
Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinson's disease.
Acquarone M, de Melo TM, Meireles F, Brito-Moreira J, Oliveira G, Ferreira ST, Castro NG, Tovar-Moll F, Houzel JC, Rehen SK. Acquarone M, et al. Among authors: houzel jc. Front Cell Neurosci. 2015 Apr 8;9:97. doi: 10.3389/fncel.2015.00097. eCollection 2015. Front Cell Neurosci. 2015. PMID: 25904842 Free PMC article.
The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.
Batista AF, Forny-Germano L, Clarke JR, Lyra E Silva NM, Brito-Moreira J, Boehnke SE, Winterborn A, Coe BC, Lablans A, Vital JF, Marques SA, Martinez AM, Gralle M, Holscher C, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG. Batista AF, et al. Among authors: houzel jc. J Pathol. 2018 May;245(1):85-100. doi: 10.1002/path.5056. Epub 2018 Apr 2. J Pathol. 2018. PMID: 29435980 Free PMC article.
Murine dopaminergic Müller cells restore motor function in a model of Parkinson's disease.
Stutz B, da Conceição FS, Santos LE, Cadilhe DV, Fleming RL, Acquarone M, Gardino PF, de Melo Reis RA, Dickson PW, Dunkley PR, Rehen S, Houzel JC, de Mello FG. Stutz B, et al. Among authors: houzel jc. J Neurochem. 2014 Mar;128(6):829-40. doi: 10.1111/jnc.12475. Epub 2013 Oct 24. J Neurochem. 2014. PMID: 24117434 Free article.
28 results